Cladosporine A, a new indole diterpenoid alkaloid with antimicrobial activities from Cladosporium sp.

Cladosporine A, a new indole diterpenoid alkaloid with antimicrobial activities from Cladosporium sp.
Nat Prod Res. 2019 Jul 15;:1-7
Authors: Han X, Bao XF, Wang CX, Xie J, Song XJ, Dai P, Chen GD, Hu D, Yao XS, Gao H
Abstract
Cladosporine A (1), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by electronic circular dichroism (ECD) experiments. This is the first report of the presence of indole diterpenoid alkaloid in the genus Cladosporium. The antimicrobial activities against Staphylococcus aureus 209P, Escherichia coli ATCC0111, Aspergillus niger R330, and Candida albicans FIM709 were evaluated. Compound 1 showed MICs of 4 μg/mL and 16 μg/mL against S. aureus 209P and C. albicans FIM709, respectively.
PMID: 31307232 [PubMed - as supplied by publisher]

Source: Natural Product Research - July 14, 2019 Category: Biochemistry Authors: Han X, Bao XF, Wang CX, Xie J, Song XJ, Dai P, Chen GD, Hu D, Yao XS, Gao H Tags: Nat Prod Res Source Type: research