Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and Dyslipidaemia

The distribution of adipose tissue is influenced by gender and by age, shifting from subcutaneous to visceral depots with longevity, increasing the development of several ageing-related diseases and manifestations such as obesity, metabolic syndrome and insulin resistance. Epigenetics might have an important role in ageing processes. The aim of this research was to investigate the interactions between ageing and epigenetic processes and the role of visceral adipose tissue, insulin resistance and dyslipidaemia. Two different study samples of 366 and 269 adult participants were analysed. Anthropometric, biochemical (including the triglycerides and glucose (TyG) index), and blood pressure measurements were assessed following standardized methods. Body composition measurements by Dual-energy X-ray absorptiometry (DXA) were also performed for the second sample. Methylation data were assessed by Infinium Human Methylation Beadchip (Illumina) in peripheral white blood cells. Epigenetic age acceleration was calculated using the methods DNAmAge (AgeAcc) and GrimAge (AgeAccGrim). Age acceleration (AgeAccGrim) showed better correlations than AgeAcc with most of the measured variables (waist circumference, glucose, HOMA-IR, HDL-cholesterol, triglycerides and TyG index) for the first sample. In the second sample, all the previous correlations were confirmed, except for HOMA-IR. In addition, many of the anthropometrical measurements assessed by DXA and C-reactive protein (CRP) were also st...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research