Influence of CYP3A5 and ABCB1 polymorphism on tacrolimus drug dosing in South Indian renal allograft recipients

Conclusions: CYP3A5 polymorphisms correlated with tacrolimus dose requirements and blood levels, incidence of early acute rejection, and tacrolimus nephrotoxicity. CYP3A5 polymorphism analysis prior to renal transplant will aid more precise early tacrolimus dose calculation to balance between rejection and toxicity.

Source: Indian Journal of Nephrology - July 15, 2019 Category: Urology & Nephrology Authors: M Edwin Fernando Manokaran Sellappan ND Srinivasa Prasad Sujit Suren K Thirumalvalavan Source Type: research