E157Q integrase strand-transfer inhibitor substitution in patients with acute/recent HIV infection

Conclusion: E157Q substitution, reducing raltegravir and elvitegravir activity, was frequently found in acute/recent HIV cases. All cases were infected with subtype B, and some were included in clusters. Cases treated with dolutegravir-based regimens had good virological response.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE: CONCISE COMMUNICATIONS Source Type: research