Roles of T875N somatic mutation in the activity, structural stability of JAK2 and the transformation of OCI-AML3 cells.

This study provides clues in understanding structural basis of T875N mutation caused JAK2 hyperactivation and its roles in the pathology of AML.
PMID: 31299252 [PubMed - as supplied by publisher]

Source: International Journal of Biological Macromolecules - July 8, 2019 Category: Biochemistry Authors: Chen C, Li F, Ma MM, Zhang S, Liu Y, Yan ZL, Chen W, Cao J, Zeng LY, Wang XY, Xu KL, Wu QY Tags: Int J Biol Macromol Source Type: research