Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 CNV Mediated Risk for Neuropsychiatric Disorders

22q11.2 copy number variants (CNVs) are among the most highly penetrant genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia (SCZ) and autism spectrum disorder (ASD). However, the specific mechanisms through which they confer risk remain unclear.

Source: Biological Psychiatry - July 10, 2019 Category: Psychiatry Authors: Jennifer K. Forsyth, Daniel Nachun, Michael J. Gandal, Daniel H. Geschwind, Ariana E. Anderson, Giovanni Coppola, Carrie E. Bearden Tags: Archival Report Source Type: research