Molecular structure elucidation with charge-state control

The charge state of a molecule governs its physicochemical properties, such as conformation, reactivity, and aromaticity, with implications for on-surface synthesis, catalysis, photoconversion, and applications in molecular electronics. On insulating, multilayer sodium chloride (NaCl) films, we controlled the charge state of organic molecules and resolved their structures in neutral, cationic, anionic, and dianionic states by atomic force microscopy, obtaining atomic resolution and bond-order discrimination using carbon monoxide (CO)–functionalized tips. We detected changes in conformation, adsorption geometry, and bond-order relations for azobenzene, tetracyanoquinodimethane, and pentacene in multiple charge states. Moreover, for porphine, we investigate the charge state–dependent change of aromaticity and conjugation pathway in the macrocycle. This work opens the way to studying chemical-structural changes of individual molecules for a wide range of charge states.
Source: ScienceNOW - Category: Science Authors: Tags: Chemistry reports Source Type: news

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Publication date: Available online 6 April 2020Source: Food Research InternationalAuthor(s): Xiaoyin Yang, Xin Luo, Yimin Zhang, David L. Hopkins, Rongrong Liang, Pengcheng Dong, Lixian Zhu
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 4 April 2020Source: Materials Chemistry and PhysicsAuthor(s): Maryam Akbari, Ali Akbar Mirzaei, Maryam Arsalanfar
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Conclusion [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Synlett - Category: Chemistry Authors: Tags: account Source Type: research
Objectives: The early identification of patients with a high risk of developing delayed neurological sequelae (DNS) can improve the quality of care in carbon monoxide (CO) poisoning cases. The aim of this study is to investigate whether the serum ne...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Hidenori Mimura An oscillating piezoresistive microcantilever (MC) coated with an aluminum (Al)-doped zinc oxide (ZnO) nanorods was used to detect carbon monoxide (CO) in air at room temperature. Al-doped ZnO nanorods were grown on the MC surface using the hydrothermal method, and a response to CO gas was observed by measuring a resonant frequency shift of vibrated MC. CO gas response showed a significant increase in resonant frequency, where sensitivity in the order of picogram amounts was obtained. An increase in resonant frequency was also observed with increasing gas flow rate, which was simultaneously followed b...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Beyond the major gene BMPR2, several new genes predisposing to PAH have been identified during the last decade. Recently, preliminary evidence of the involvement of the KDR gene was found in a large genetic association study. We prospectively analysed the KDR gene by targeted panel sequencing in a series of 311 PAH patients referred to a clinical molecular laboratory for genetic diagnosis of PAH. Two index cases with severe PAH from two different families were found to carry a loss-of-function mutation in the KDR gene. These two index cases were clinically characterised by low diffusing capacity for carbon monoxide adjuste...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Mechanisms of lung disease, Pulmonary vascular disease Original Articles: Pulmonary hypertension and basic science Source Type: research
Authors: Park J, Kim J, Chen Y, Song HC, Chen Y, Zheng M, Surh YJ, Kim UH, Park JW, Joe Y, Chung HT Abstract Oxidative stress is recognised as a key factor that can lead to cellular senescence and aging. Carbon monoxide (CO) is produced by haemoxygenase-1 (HO-1), which exerts cytoprotective effects in aging-related diseases, whereas the effect of CO on cellular senescence and aging has not been elucidated. In the current study, we clearly demonstrated that CO delays the process of cellular senescence and aging through regulation of miR-34a and Sirt1 expression. CO reduced H2O2-induced premature senescence in human ...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
id A. Groneberg Although the big tobacco companies offer the same cigarette brands across countries, little is known about the potential regional differences of the particulate matter (PM) emissions of apparently equal brands. PM emissions of three cigarette brands (Marlboro Gold, Winston Red resp. Classic, Parliament Platinum resp. Night Blue) from the United Arab Emirates (UAE) and Germany were analysed. Second-hand smoke was produced in a 2.88 m3 measuring cabin by an automatic environmental tobacco smoke emitter. PM size fractions PM10, PM2.5, and PM1 were detected in real-time using laser aerosol spectrometry. Dep...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Objectives Carbon monoxide (CO) poisoning is a common and deadly form of poisoning that is often treated with hyperbaric oxygen. The characteristics of children exposed to CO and then treated with hyperbaric oxygen have not been delineated. The purpose of this study was to describe the clinical characteristics of children treated with hyperbaric oxygen therapy for CO poisoning at a regional hyperbaric referral center. Methods The study is based on a retrospective review of data extracted from the medical records of children (age
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Original Articles Source Type: research
DLCO measures gas movement at the alveolar-capillary interface. The DLCO at CLAD onset predicts post-CLAD survival. We hypothesized that DLCO is a sensitive measure of allograft fibrosis which would be reflected in the CLAD phenotype. Our aim was to describe the trajectory of DLCO measurements after lung transplantation based on CLAD phenotype.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (753) Source Type: research
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