Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study

AbstractObstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). We retrospectively analyzed OFDI data for coronary artery plaques from 15 patients with OSA and 35 non –OSA patients treated between October 2015 and October 2018. Plaque morphology was evaluated for 70 lesions, including 21 from patients with OSA and 49 from non–OSA patients. Compared with the non–OSA group, patients with OSA had significantly higher prevalences of thinned cap fibroatheroma (T CFA) (67% vs. 35%,P = 0.014) and microchannels (86% vs. 55%,P = 0.014); a significantly higher mean lipid index (1392 ± 982 vs. 817 ± 699,P = 0.021), macrophage grade (8.4 ± 6.4 vs. 4.8 ± 4.5,P = 0.030), and maximum number of microchannels (1.5 ± 1.0 vs. 0.7 ± 0.7,P = 0.001); and a significantly lower mean minimum fibrous cap thickness (69.4 ± 28.7 vs. 96.1 ±...
Source: Heart and Vessels - Category: Cardiology Source Type: research

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ConclusionAmong patients with AF, OSA is an independent risk factor for MACNE and, more specifically, stroke/SE.Graphical Abstract
Source: American Heart Journal - Category: Cardiology Source Type: research
Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) may influence the prognosis of acute ischemic stroke (AIS). Our objective is to study the impact of early screening and treatment of OSAHS in AIS.Methods: 24 patients with AIS
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
This study aimed to evaluate the incidence of CV and CeV events and related mortality in 89 males with moderate-to-severe OSA treated with PAP over 10 years, and to assess its relation with PAP adherence.Results: Of 89 patients included (mean age 53.5±11.7 years, BMI=33.2±4.9 kg/m2, initial AHI=52.9±20.6 events/h, Epworth scale=12.2±5.3), 17 were active smokers, 63 had hypertension, 1 hyperuricemia, and 5 had previous CV/CeV events. Over follow-up, AHI and Epworth scale decreased significantly (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
ConclusionsIn AF patients, there is underuse of GDT for non-AF comorbidities. The association between GDT use and outcomes was strongest in heart failure and obstructive sleep apnea patients where use of GDT was associated with lower mortality and less AF progression.
Source: American Heart Journal - Category: Cardiology Source Type: research
Conclusions: Obstructive sleep apnea diagnosis in atrial fibrillation patients was strongly associated with reduced risk of incident cardiovascular disease. We discuss misclassification, selection bias, and residual confounding as potential explanations.
Source: Epidemiology - Category: Epidemiology Tags: Sleep Source Type: research
FRIDAY, Aug. 16, 2019 -- Continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea can ease depression in people with heart disease, according to a groundbreaking new study. " Patients who have had a stroke or heart attack are...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This study, the first large scale screening for OSA in Poland, shows a substantial, much higher than previously appreciated, prevalence of risk for OSA in the population at large. PMID: 31372855 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this techniqu...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we used HUT as the means to provide an all-encompassing assessment of cardiac and/or peripheral autonomic function in normal controls, SCD subjects and non-SCD subjects with chronic anemia. We hypothesized that by identifying different categories of HUT response among these subjects, we would be able to isolate the autonomic phenotypes that might place SCD subjects at increased risk for microvascular occlusion and VOC. We then employed the causal modeling approach, which utilizes signal analysis and system identification techniques, to probe and disentangle the functional mechanisms involved in the cardiovas...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: In the present model-based analysis, UAS therapy provides meaningful benefit to patient-relevant endpoints and is a cost-effective therapy in the German setting.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
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