cAMP-MicroRNA-203-IFNγ Network Regulates Subcutaneous White Fat Browning and Glucose Tolerance

ConclusionsMicroRNA-203 (miR-203) promotes white adipose tissue browning in cold exposed mice and improves glucose tolerance in HFD fed mice by repressing IFN-γ.Since miR-203 is activated by cAMP-dependent C/EBPβ up-regulation and directlyrepressesIFN-γ signal pathway, we declare that miR-203 acts as a messenger between cAMP signal pathway and IFN-γ signal pathway.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research