Homogeneously Staining Region (hsr) on Chromosome 11 Is Highly Specific for KMT2A Amplification in Acute Myeloid Leukemia (AML) and Myelodysplastic syndrome (MDS)

Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are common myeloid neoplasms that affect mainly older patients [1]. Both AML and MDS are heterogeneous groups of diseases that are subclassified into multiple types based on clinical, pathologic and genetic abnormalities; many of them show substantial differences in prognosis and ultimate outcome and, in some instances, require different therapeutic interventions [2,3]. Overexpression of certain proto-oncogenes plays an indispensable role in tumorgenesis of AML and MDS and results in enhanced proliferation and impaired differentiation of leukemic stem cells [4,5].

Source: Cancer Genetics and Cytogenetics - July 4, 2019 Category: Genetics & Stem Cells Authors: Ali Sakhdari, Zhenya Tang, Chi Young Ok, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Yang O. Huh Tags: Original Article Source Type: research