Cerebral hunger maps in rodents and humans by diffusion weighted MRI.

Cerebral hunger maps in rodents and humans by diffusion weighted MRI. Appetite. 2019 Jun 25;:104333 Authors: Benítez A, Lizarbe B, Guadilla I, López-Larrubia P, Lago-Fernández LF, Cerdán S, Sánchez-Montañés M Abstract We design, implement and validate a novel image processing strategy to obtain in vivo maps of hunger stimulation in the brain of mice, rats and humans, combining Diffusion Weighted Magnetic Resonance Imaging (DWI) datasets from fed and fasted subjects. Hunger maps were obtained from axial/coronal (rodents/humans) brain sections containing the hypothalamus and coplanar cortico-limbic structures using Fisher's Discriminant Analysis of the combined voxel ensembles from both feeding situations. These maps were validated against those provided by the classical mono-exponential diffusion model as applied over the same subjects and conditions. Mono-exponential fittings revealed significant Apparent Diffusion Coefficient (ADC) decreases through the brain regions stimulated by hunger, but rigorous parameter estimations imposed the rejection of considerable number of pixels. The proposed approach avoided pixel rejections and provided a representation of the combined DWI dataset as a pixel map of the "Hunger Index" (HI), a parameter revealing the hunger score of every pixel. The new methodology proved to be robust both, by yielding consistent results with classical ADC maps and, by reproducing...
Source: Appetite - Category: Nutrition Authors: Tags: Appetite Source Type: research

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