Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor-κB and NLRP3 Inflammasome Activation.

CONCLUSIONS: The in vivo study clearly demonstrates that artemisinin has protective effects on AD pathology due to its effects on suppressing NF-κB activity and NALP3 inflammasome activation. Our study suggests that targeting NF-κB activity and NALP3 inflammasome activation offers a valuable intervention for AD. PMID: 23406388 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/PubMed/23406388?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 14, 2013 Category: Neuroscience Authors: Shi JQ, Zhang CC, Sun XL, Cheng XX, Wang JB, Zhang YD, Xu J, Zou HQ Tags: CNS Neurosci Ther Source Type: research