Estimated Glomerular Filtration Rate and Muscle Mass: Their Relationship in Older Inpatients

The assessment of renal function drives many therapeutic and diagnostic decisions in everyday practice. Serum creatinine concentration (Cr) provides an unreliable estimate of glomerular filtration rate (eGFR), the optimal measure of which relies on exogenous substances. Because this is unfeasible in daily practice, the surrogate eGFR through Cr-based equations has become the clinical standard. The age-related decline of muscle mass may affect Cr and influence eGFR. The Modification Diet in Renal Disease 4-variable (MDRD),1 the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI),2 and Berlin Initiative Study 1 (BIS-1)3 equations were computed using data from populations with different age composition.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Research Letter Source Type: research