TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance.

CONCLUSIONS: Our data not only define the essential role of TWIST1 as an EMT-TF in APL patients but also suggest that disrupting the TRIB3/TWIST1 interaction reverses induction therapy resistance and blocks rapid progression of APL early death.
PMID: 31235507 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - June 23, 2019 Category: Cancer & Oncology Authors: Lin J, Zhang W, Niu LT, Zhu YM, Weng XQ, Sheng Y, Zhu J, Xu J Tags: Clin Cancer Res Source Type: research