Dissecting Gene Repression: Not Just Location, Location, Location.

Dissecting Gene Repression: Not Just Location, Location, Location.
Trends Cell Biol. 2019 Jun 21;:
Authors: Sexton T
Abstract
Large heterochromatic domains are found tethered to the lamina. But, is this nuclear environment repressive per se, or just the 'ground state' of inactive chromatin? Elegant studies from the van Steensel group (Leemans et al., Cell, 2019) recently demonstrated that the lamina is indeed repressive, but that intrinsic promoter properties also dictate gene activity.
PMID: 31235204 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - June 20, 2019 Category: Cytology Authors: Sexton T Tags: Trends Cell Biol Source Type: research