Intracardiac administration of neutrophil protease cathepsin G activates noncanonical inflammasome pathway and promotes inflammation and pathological remodeling in non-injured heart

This study investigated whether neutrophil-derived cathepsin G (Cat.G) influences inflammation and remodeling in the absence of prior cardiac injury and cell death.

Source: Journal of Molecular and Cellular Cardiology - June 24, 2019 Category: Cytology Authors: Sonni-Ali Miller, Mikhail A. Kolpakov, Xinji Guo, Binbin Du, Yen Nguyen, Tao Wang, Pamela Powel, Louis J. Dell'Italia, Abdelkarim Sabri Source Type: research