Canonical Wnt Signaling Promotes Neovascularization through Determination of Endothelial Progenitor Cell Fate via Metabolic Profile Regulation

This study found that EPC metabolic profile is a direct determinant of EPC fate. The Wnt signaling pathway regulates EPC metabolism, EPC fate and subsequently, new vessel formation. These findings reveal a new function of Wnt signaling in regulating mitochondrial function in EPC. This study also suggests a potential significance of EPC metabolic profile as a diagnostic marker and therapeutic target for diseases caused by abnormal blood vessel formation.© AlphaMed Press 2019

Source: Stem Cells - June 23, 2019 Category: Stem Cells Authors: Yan Shao, Jianglei Chen, Willard Freeman, Li ‐jie Dong, Zhi‐hui Zhang, Manhong Xu, Fangfang Qiu, Yanhong Du, Juping Liu, Xiao‐rong Li, Jian‐xing Ma Tags: Tissue ‐Specific Stem Cells Source Type: research