Preoperative Staging by EBUS in cN0/N1 Lung Cancer: Systematic Review and Meta-Analysis

Conclusion: Preoperative systematic staging by EBUS-TBNA of early lung cancer can reduce postoperative upstaging. Sensitivity for detection of radiologically occult mediastinal metastases seems lower than selective sampling of pathologic lymph nodes. Verification of negative results by mediastinoscopy in selected cases remains of value.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research

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This article summarizes the milestones in the development of camrelizumab leading to this first approval for classical Hodgkin lymphoma.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Conditions:   Lung Cancer;   Esophageal Cancer Intervention:   Sponsor:   Chinese Academy of Medical Sciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractThe goal of this study was to further characterize respiratory patterns in total laryngectomees with attention to respiratory-swallow pattern as it relates to presence/absence of tracheoesophageal puncture (TEP) and bolus consistency. It was hypothesized that participants with TEP would exhibit respiratory-swallow patterns that were significantly different than those without TEP and that bolus consistency (thin or solid) would modulate respiratory-swallow pattern. Data were collected from 12 adults (8 male), aged 46 –67 years (mean 57) status post total laryngectomy (1–30 years; average 6 ...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
ConclusionThe results reveal the frequency of these biomarkers in different malignancies, with potential implications for PD ‐1/PD‐L1 blockade use for Chinese patients with cancer.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We report this rare case of aortoesophageal fistula treated using TEVAR. However, the therapeutic effect was temporary. Further studies investigating the indications for TEVAR are warranted. PMID: 31243231 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 25 June 2019Source: Practical Radiation OncologyAuthor(s): Sarah Z. Hazell, Russell K. Hales, William T. Hrinivich, Kristy Ford, Ken Kang-Hsin Wang, Todd R. McNutt, Peijin Han, Lori J. Anderson, Adam C. Ferro, Joseph Moore, Khinh Ranh VoongAbstractIntroductionNon-homogeneous dose optimization (NHDO) is exploited in stereotactic body radiotherapy (SBRT) to increase dose delivery to the tumor and allow rapid dose fall-off to surrounding normal tissues. We investigate changes in plan quality when NHDO is applied to conventionally-fractionated inverse-planned radiation (CF-RT) plans, in patie...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
This report also highlights the use of above mentioned novel therapeutic methods for successful management of these complications in these frail patients.
Source: Annals of Thoracic Medicine - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSIONS: SBRT was well-tolerated in the treatment of stage I SCLC with excellent LC achieved. Patients with T1N0 stage IA SCLC were noted to have improved PFS and OS following SBRT as compared with T2N0 Stage IB SCLC. Adjuvant chemotherapy was found to result in improved OS for stage I SCLC patients over SBRT alone. PMID: 31232723 [PubMed - in process]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Am J Clin Oncol Source Type: research
Endoscopic ultrasound (with bronchoscope) fine needle aspiration (EUS-B-FNA) has been recognized as a useful and safe technique in sampling mediastinal lymph nodes. Few data are available on its accuracy in diagnosing pulmonary parenchymal lesions adjacent to the esophagus.We performed an observational, retrospective study aimed to evaluate accuracy and safety of EUS-B-FNA for lung parenchymal abnormalities, in two Italian reference centers. Furthermore, impact of rapid on-site evaluation (ROSE) and lesion anatomical site (i.e. lobe) on diagnostic yield were assessed.From November 2016 to January 2018, 21 patients (52.4% m...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research
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