The net clinical benefits of febuxostat versus allopurinol in patients with gout or asymptomatic hyperuricemia – a systematic review and meta-analysis

Systemic reviews and meta-analyses suggest hyperuricemia is a cardiovascular risk factor. The effects of xanthine oxidase inhibitors on cardiac outcomes remain unclear. We assessed the effects of febuxostat and allopurinol on mortality and adverse reactions in adult patients with hyperuricemia.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Tags: Systematic Reviews and Meta-analyses Source Type: research

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Publication date: Available online 14 July 2019Source: Pharmacological ResearchAuthor(s): Federica Raucci, Asif J. Iqbal, Anella Saviano, Paola Minosi, Marialuisa Piccolo, Carlo Irace, Francesco Caso, Raffaele Scarpa, Stefano Pieretti, Nicola Mascolo, Francesco MaioneAbstractGout is a paradigm of acute, self-limiting inflammation caused by the deposition of monosodium urate (MSU) crystals within intra-and/or peri-articular areas, which leads to excruciating pain, joint swelling and stiffness. The infiltration of leukocytes drives the inflammatory response and remains an attractive target for therapeutic intervention. In th...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Study indicates that wearing hearing aids could boost aspects of memory and attention in healthy older people Related items fromOnMedica Virtual reality could help spot Alzheimer ’s quicker Dementia leading cause of death in women over 80 Risk of Alzheimer ’s lower in people with gout WHO issues guidelines on dementia risk reduction LGBT community at higher risk of cognitive decline
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MONDAY, July 15, 2019 -- More than one-fourth of patients with acute gout discharged from the emergency department receive an opioid prescription, according to a study published online July 2 in Arthritis Care&Research. Deepan S. Dalal, M.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Bao-Bao Shi, Jing Chen, Mei-Fen Bao, Ying Zeng, Xiang-Hai CaiAbstractContinued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A–D (1–4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoq...
Source: Phytochemistry - Category: Chemistry Source Type: research
Source: FDA Drug Safety Podcasts - Category: Drugs & Pharmacology Authors: Source Type: podcasts
Source: FDA Drug Safety Podcasts - Category: Drugs & Pharmacology Authors: Source Type: podcasts
Footwear is an important concern for people with gout, who often describe difficulty finding suitable footwear. Previous studies have identified footwear as a major concern for people with gout. The aim of thi...
Source: Journal of Foot and Ankle Research - Category: Podiatry Authors: Tags: Research Source Type: research
Nearly three in 10 patients seeking care at the emergency department (ED) for acute gout will be discharged with a prescription for opioids, new research shows.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Rheumatology News Source Type: news
PMID: 31297604 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
ConclusionsIn the presence of elevated urate, human cartilage homogenates increase MSU crystal formation and promote the formation of smaller crystals which have greater inflammatory potential. These processes may contribute to the predilection of gout to osteoarthritic joints.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
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