Automated Plasma Assays for Alzheimer Disease –Related β-Amyloid Status

This corss-sectional diagnostic study evaluates the accuracy of fully automated plasma assays in measuring plasma β-amyloid and tau in patients with and without cognitive impairment in the Swedish BioFINDER study and an independent validation cohort.
Source: JAMA Neurology - Category: Neurology Source Type: research

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Authors: Mydlikowska-Śmigórska A, Śmigórski K, Rymaszewska J Abstract Changes in the olfactory ability are one of early symptoms of developing neurodegenerative diseases, especially Parkinson's disease and Alzheimer's disease. In a healthy population olfactory function is characterized by independence from an intelligence quotient and various cognitive functions, e.g., memory. The peak of the olfactory ability falls between 20 and 40 years of age. In the geriatric population the worsening of the olfactory ability is found. Because of it, the knowledge on differences between the changes associated wi...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Publication date: Available online 18 July 2019Source: Nitric OxideAuthor(s): Xiaoyi Tang, Zhuang Li, Weiwei Zhang, Zhongxiang YaoAbstractAlzheimer's disease (AD) is a typical neurodegenerative disease in central nervous system (CNS). Generally speaking, patients with severe AD are often accompanied with cognitive impairment. Oligodendrocytes (OLs) are myelin-forming cells in CNS, and myelin injury potentially has something to do with the cognitive impairment in AD. Based on the previous experimental studies, it has been recognized that nitric oxide (NO), as a signaling molecule, might have an influence on the axon and mye...
Source: Nitric Oxide - Category: Chemistry Source Type: research
Increased Neuronal Nuclear and Perikaryal Size in the Medial Mamillary Nucleus of Vascular Dementia and Alzheimer's Disease Patients: Relation to Nuclear Estrogen Receptor α. Dement Geriatr Cogn Disord. 2019 Jul 18;:1-7 Authors: Ishunina TA, Bogolepova IN, Swaab DF Abstract BACKGROUND: The hypothalamic medial mamillary (MMN) and the tuberomamillary (TMN) nuclei are important hubs in memory circuits. Previous studies determining the neuronal Golgi complex size showed decreased metabolic activity of the TMN neurons in both Alzhei-mer's disease (AD) and vascular dementia (VD), and no obvious decline...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
In this study, we verify the impact of CDIP parameters compliance on total brain volume variance using 86 scans of the same individual acquired on various scanners. Data included planned data collection acquired within the Consortium pour l'identification précoce de la maladie Alzheimer - Québec (CIMA-Q) and Canadian Consortium on Neurodegeneration in Aging (CCNA) studies, as well as opportunistic data collection from various protocols. For images acquired from Philips scanners, lower variance in brain volumes were observed when the stated CDIP resolution was set. For images acquired from GE scanners, lower v...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
New research indicates biological differences might be a reason more women are affected by Alzheimer ’s disease than men.  Although the prevailing thought had been Alzheimer’s affects more women because they tend to live longer, scientists this week at the Alzheimer’s Association International Conference in Los Angeles explained that a toxic protein called tau, which destroys nerve cells, s preads more easily through women’s brains than men’s, the Associated Press reports.  It also…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Between 1998 and 2017, there were nearly 150 Alzheimer's drugs in development that failed to receive regulatory approval.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Abstract Identification of tyrosine Fyn kinase inhibitor is recognized as an effective and feasible therapeutic measure in reducing consequences of memory loss disorder Alzheimer's. The present investigation has been attempted with an objective to find out a novel potent inhibitor with similar homological structure to Fyn kinase using structure based in silico screening measure. Such derived structure was compared with natural data base pool and were systematically analyzed. Ligand based interaction was also tested and evaluated. We applied a molecular dynamic simulation technique to validate the stability of the ...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Authors: Lu X, Yang B, Yu H, Hu X, Nie J, Wan B, Zhang M, Lü C Abstract Context: Neuroligin-1 (NLGN1) is a cell adhesion protein located on the excitatory postsynaptic membrane. β-Amyloid (Aβ)-induced neuroinflammation decreases NLGN1 expression through epigenetic mechanisms. Triptolide (T10) and tripchlorolide (T4) exert protective effects on synapses in Alzheimer's disease (AD) mice, but the mechanisms remain unclear. Objective: The effects of T10 and T4 on hippocampal NLGN1 expression in AD mice and the epigenetic mechanisms were assessed using chromatin immunoprecipitation and methylated DNA immu...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Swedish and Canadian researchers have developed a four-stage model that uses...Read more on AuntMinnie.comRelated Reading: PET shows how women are more susceptible to Alzheimer's Florbetapir-PET links lack of financial acumen to dementia IDEAS study confirms amyloid PET's value for Alzheimer's Are amyloid PET scans ready for the clinical setting? PET links sleep and beta-amyloid accumulation
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(University of Pennsylvania School of Medicine) As cells age, their ability to shed harmful refuse declines. New research suggests that the deterioration of autophagy in aged neurons could be a risk factor for a suite of neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis), Alzheimer's, and Parkinson's.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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