Do the posterior midline cortices belong to the electrophysiological default-mode network?

Publication date: Available online 22 June 2019Source: NeuroImageAuthor(s): Martin Sjøgård, Xavier De Tiège, Alison Mary, Philippe Peigneux, Serge Goldman, Guy Nagels, Jeroen van Schependom, Andrew J. Quinn, Mark Woolrich, Vincent WensAbstractThe default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture. Because of their centrality, they are affected by a wide spectrum of brain disorders, e.g., Alzheimer's disease. Non-invasive electrophysiological techniques such as magnetoencephalography (MEG) are crucial to the investigation of the neurophysiology of the DMN and its alteration by brain disorders. However, MEG studies relying on band-limited power envelope correlation diverge in their ability to identify the PMC as a part of the DMN in healthy subjects at rest. Since these works were based on different MEG recording systems and different source reconstruction pipelines, we compared DMN functional connectivity estimated with two distinct MEG systems (Elekta, now MEGIN, and CTF) and two widely used reconstruction algorithms (Minimum Norm Estimation and linearly constrained minimum variance (LCMV) Beamformer). Our results identified the reconstruction method as the critical factor influencing PMC functional connectivity, which was significantly dampened by the LCMV Beamformer. On this ba...
Source: NeuroImage - Category: Neuroscience Source Type: research

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Publication date: Available online 17 July 2019Source: Neuroscience LettersAuthor(s): Rehana Khatoon, Md. Zeeshan Rasheed, Mahika Rawat, Mohd. Mumtaz Alam, Heena Tabassum, Suhel ParvezAbstractAlzheimers’s disease is one of the alarming neurodegenerative disease and it is of global concern.The hallmarks of the disease are the amyloid beta (Aβ) aggregation and presence of neurofibrillary tangles (NFTs). The interaction of Aβ with macromolecular targets affects the normal cellular functions. The amyloid peptide interaction with cellular surfaces may trigger the intracellular cascades of signalling. Interaction...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
CONCLUSIONS: We highlight the frequent presence of amyloid pathology in prodromal LBD in our population, and the probable involvement of different metabolic pathways in the same clinically defined dementia. PMID: 31309997 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
AbstractBiomarkers classically studied in Alzheimer ’s disease have been analyzed in numerous central nervous system infections in adults, but there are scarce data on these biomarkers in children. Enteroviruses appear to be the most common cause of aseptic meningitis throughout the world. The aim of the study was to investigate neuroinflammatory p roperties of non-polio enteroviruses by measuring CSF concentrations of biomarkers that are involved in neuropathological pathways of neurodegenerative disorders. We measured Aβ42, t-tau, and S100B concentrations in 42 children with enteroviral meningitis (EM) compare...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
The global race to create an inexpensive and accessible blood test for Alzheimer disease is heating up. Experts project that such a test could be available in just a few years.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
CONCLUSIONS: Our findings imply a shared underlying pathology relating MS and brain volume and suggest cognitive functional declines through the muscle-brain axis. Further longitudinal studies are needed to find possible and related causes of reduced MS and cortical atrophy in patients with dementia. PMID: 31311027 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSIONS: Reduction in Αβ42 in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression. PMID: 31311013 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
PET images have uncovered consistently greater accumulation of tau protein...Read more on AuntMinnie.comRelated Reading: PET, MRI show physical activity aids brain health PET links sleep and beta-amyloid accumulation How do seniors react to amyloid-PET results? PET study links menopausal status to Alzheimer's FDG-PET links physical activity to healthy brains
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(The Korea Advanced Institute of Science and Technology (KAIST)) KAIST researchers have identified somatic mutations in the brain that could contribute to the development of Alzheimer's disease (AD).
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Source: Clinical Interventions in Aging - Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
IJERPH, Vol. 16, Pages 2560: The Role of Eicosanoids in Alzheimer’s Disease International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16142560 Authors: Roger G. Biringer Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders known. Estimates from the Alzheimer’s Association suggest that there are currently 5.8 million Americans living with the disease and that this will rise to 14 million by 2050. Research over the decades has revealed that AD pathology is complex and involves a number of cellular processes. In addition to the well-studied...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
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