miR-26a-5p enhances cells proliferation, invasion and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway.

CONCLUSIONS: Our study suggested that miR-26a-5p has a complementary role in cells proliferation, invasion and apoptosis of RA-FLS, which may be attributed to its activation effect on PI3K/AKT signaling pathway via targeting PTEN. miR-26a-5p is likely to be a clinically helpful target for novel therapeutic strategies in RA.
PMID: 31221815 [PubMed - as supplied by publisher]

Source: Bioscience Reports - June 19, 2019 Category: Biomedical Science Authors: Huang Z, Xing S, Liu M, Deng W, Wang Y, Huang Z, Huang Y, Huang X, Wu C, Guo X, Pan X, Jiang J, Feng F, Li T Tags: Biosci Rep Source Type: research