Hyperglycemia and Cancer: A State-of-the-Science Review.

This article discusses normal glucose regulation and hyperglycemic pathways, hyperglycemia in patients with cancer, hyperglycemia and cancer-related inflammation, and outcomes (e.g., infections, mortality, symptoms). IMPLICATIONS FOR RESEARCH: Understanding the contributors to and consequences of hyperglycemia can guide the development of screening tools to predict which individuals are at the greatest risk for hyperglycemic episodes prior to starting cancer therapies. Research can lead to glycemic guidelines specific to patients with cancer for better outcomes. PMID: 31225836 [PubMed - in process]
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research

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This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery systems that employ external- and internal-based stimuli and that are emerging as promising tools for cancer therapeutics in clinical settings.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere w...
Source: Progress in Lipid Research - Category: Lipidology Source Type: research
Publication date: Available online 21 August 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Hocheol Lim, Xuemei Jin, Jongwan Kim, Sungbo Hwang, Ki Beom Shin, Jiwon Choi, Kyoung Tai NoAbstractX-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) target for cancer therapies. We used the fragment molecular orbital (FMO) method to study the binding modes and affinities between XIAP-BIR3 and a series of its inhibi...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
In this study, four novel ball-type Pc compounds were synthesized with 1,2-benzenediol as a substituent, including one non-metal complex (H4Pc2) and three metal-containing complexes (Mg2Pc2, Co2Pc2, and Zn2Pc2). The structures of the synthesized compounds were characterized using common spectroscopic methods. Quantum yields for fluorescence (ΦF), triplet state (ΦT), singlet oxygen (ΦΔ), and photodegradation (Φd) were measured except Co2Pc2 in dimethylsulfoxide. All the three compounds exhibited low fluorescence quantum yield, high triplet quantum yield, and good stability in organic solvent, suggestin...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
Thorough understanding of growth and evolution of tissue vasculature is fundamental to many fields of medicine including cancer therapy, wound healing, and tissue engineering. Angiogenesis, the growth of new vessels from existing ones, is dynamically influenced by a variety of environmental factors, including mechanical and biophysical factors, chemotactic factors, proteolysis, and interaction with stromal cells. Yet, dynamic interactions between neovessels and their environment are difficult to study with traditional fixed time imaging techniques. Advancements in imaging technologies permit time-series and volumetric imag...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionsMultiscale approach ’s predictive capabilities are based on the fundamental scientific knowledge. Their strength is in relation to actual physical, chemical, and biological processes that take place following the ions incidence on tissue. This makes the approach flexible and versatile to include various conditions, s uch as the degree of aeration or the presence of sensitizing nanoparticles, related to particular cases. The ideas for how the MSA can contribute to an improved optimization of therapy planning are summarized in the review.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research
Broader recommendations on screening for BRCA1/2 genetic mutations published...Read more on AuntMinnie.comRelated Reading: Men need breast cancer screening too MRI finds breast cancer early in women with family history PET tracers help guide breast cancer therapies Breast cancer mutation increases interval cancer risk Screening breast MRI alone OK for high-risk women
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 20 August 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Dong-Yi Chen, Wen-Kuan Huang, Victor Chien-Chia Wu, Wen-Cheng Chang, Jen-Shi Chen, Cheng-Keng Chuang, Pao-Hsien ChuImmune checkpoint inhibitors (ICIs) are a novel treatment option for cancer therapy, which help direct the immune system to recognize and target cancer cells. ICIs have been shown to provide significant mortality benefits for cancer patients, but they are also associated with immune-mediated toxicity. Unlike most immune-related adverse events, which are a common occurrence, reversible and can be treat...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Background: Persistent hair disorders resulting from cytotoxic or endocrine agents used in early stages of breast cancer such as alopecia, hirsutism, and madarosis develop in 4-35% of patients, however their impact on quality of life (QoL) has not been reported. The CHANCE study is a prospective, longitudinal study of chemotherapy- and endocrine therapy-induced hair, skin, and nail changes in women with nonmetastatic breast cancer. This preliminary analysis intends to evaluate the impact of permanent hair sequelae of adjuvant breast cancer therapies on patients ’ QoL.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 20 August 2019Source: Seminars in Cancer BiologyAuthor(s): Sobiya Zafar, Sarwar Beg, Sunil K Panda, Mahfoozur Rahman, Khalid S Alharbi, Gaurav K Jain, Farhan J AhmadAbstractCancer, being the most prevalent and resistant disease afflicting any gender, age or social status, is the ultimate challenge for the scientific community. The new generation therapeutics for cancer management has shifted the approach to personalized/precision medicine, making use of patient- and tumor-specific markers for specifying the targeted therapies for each patient. Peptides targeting these cancer-specific sign...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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