The Evolving Modern Management of Brain Metastasis.

The Evolving Modern Management of Brain Metastasis. Clin Cancer Res. 2019 Jun 18;: Authors: Fecci PE, Champion CD, Hoj J, McKernan C, Goodwin CR, Kirkpatrick J, Anders CK, Pendergast AM, Sampson JH Abstract The incidence of brain metastases is increasing as cancer therapies improve and patients live longer, providing new challenges to the multidisciplinary teams that care for these patients. Brain metastatic cancer cells possess unique characteristics that allow them to penetrate the blood brain barrier, colonize the brain parenchyma, and persist in the intracranial environment. Additionally, brain metastases subvert the innate and adaptive immune system, permitting evasion of the anti-tumor immune response. Better understanding of the above mechanisms will allow for development and delivery of more effective therapies for brain metastases. In this review, we outline the molecular mechanisms underlying development, survival, and immunosuppression of brain metastases. We also discuss current and emerging treatment strategies, including surgery, radiation, disease-specific and mutation-targeted systemic therapy, and immunotherapy. PMID: 31213459 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research