Medical News Today: Why do women face higher heart disease risk after breast cancer?

New research confirms that women who have undergone breast cancer therapy are more at risk of cardiovascular disease, and it also shows why this may be.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

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Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human diseases. FI...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Mortality rates for cancer have diminished slowly and steadily over the past few decades. This is a matter of prevention on the one hand and improvements in early detection of cancer on the other. When caught early enough, even comparatively crude approaches to therapy have a decent chance of controlling and eliminating the cancer. This trend will no doubt continue, but the more rapid, more effective progress that we'd like to see will only emerge given the advent of universal cancer therapies, those that strike at mechanisms, such as telomere lengthening, that are shared by many or all cancers. That is a plausible goal fo...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Adjuvant whole-breast radiotherapy is a recommended part of breast-cancer therapy after breast-conserving surgery. It reduces the recurrence rates of breast cancer, specific mortality from breast cancer as well as the overall mortality [1]. However, breast-cancer radiotherapy also increases the incidence of second cancers, mainly in the contralateral breast and in the lungs. Especially for left-sided tumours it also increases the mortality through heart disease [1,2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original article Source Type: research
Abstract BACKGROUND: Cardiovascular disease (CVD) and cancer are major causes of death in Japan. As most CVDs are chronic and often aggravate, long-term follow-up is necessary. Although some cancer patients and survivors have CVD, its prognostic significance and prevalence are unknown. Therefore, we conducted a retrospective study at our center to determine the prevalence of cancer patients with CVD. METHODS: In 2015, our 10-year (2005-2014) cancer registry was summarized. Comorbidities including left ventricular dysfunction, atrial fibrillation (AF), ischemic heart disease, aortic stenosis, venous thromboemb...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Int J Clin Oncol Source Type: research
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Many breast cancer therapies cause damage to the heart. However, in the largest study of its kind so far, scientists from the German Cancer Research Center (DKFZ) in Heidelberg have now shown that the risk of death from heart disease in breast cancer patients following radiotherapy or chemotherapy is no higher than it is among the average population. Good risk management in the hospitals as well as control screenings at short intervals seem to make up for elevated risks.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Journal of Cardiovascular Disease Research,2018,9,1,1-4.DOI:10.5530/jcdr.2018.1.1Published:March 2018Type:Review ArticleBreast Cancer and the Heart: Burden on the ChestAjit Singh,Hashir Kareem,Tom Devasia,Kanav Khera,Sheetal Chauhan,Yeswanth Rao K,andGanesh PAjit Singh*1, Hashir Kareem1, Tom Devasia1, Kanav Khera2, Sheetal Chauhan3, Yeswanth Rao K3, Ganesh P11Department of Cardiology, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.2Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA...
Source: Journal of Cardiovascular Disease Research - Category: Cardiology Authors: Source Type: research
Some breast cancer treatments may raise the risk of heart disease, according to a warning issued by the American Heart Association. Patients should still undergo lifesaving treatments but not neglect their heart health, doctors say.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: The occurrence of MI is very low in this cohort (4.4%), reassuring the clinicians that the older adults with comorbidities may not be at a higher risk of MI with adjuvant endocrine therapy. However, the confidence interval for the hazard ratio of AIs vs Tamoxifen is very wide, indicating that a larger sample may be needed for the power of the study to be conclusive.Citation Format: Kamaraju S, Smith E, Shi Y, Laud P, Neuner J. Are aromatase inhibitors associated with higher myocardial infarction risk in breast cancer patients? A Medicare population study [abstract]. In: Proceedings of the Thirty-Ninth Annual C...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Discussion Abstracts Source Type: research
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