Expression of serine proteases in neutrophils from women and men: regulation by endocrine disruptor bisphenol A

Publication date: Available online 18 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Wioletta Ratajczak-Wrona, Karolina Nowak, Marzena Garley, Kamil Grubczak, Dorota Dabrowska, Agnieszka Iwaniuk, Sara Wilk, Marcin Moniuszko, Jan Czerniecki, Slawomir Wolczynski, Ewa JablonskaAbstractBisphenol A (BPA) is a well-known endocrine disruptor. However, little information is available about its immunological effects. In the present study, we aimed to evaluate cytotoxic activity of BPA on human polymorphonuclear neutrophils (PMNs) according to gender and examine its effect on the expression of neutrophil serine proteases. Results indicated that exposure to BPA (above 16 μM) leads to a decrease in viability of PMNs and to morphological changes in these cells of both genders. The experiments showed different effects of BPA on the expression of proteinase 3, elastase, and cathepsin G in PMNs of both men and women, depending on the gender and concentration used. Thus, our findings suggest for the first time that through dysregulation of the expression of these enzymes, BPA may lead to disorders of the nonspecific cellular response in people exposed to this xenoestrogen.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research