A Novel Translational Ovine Pulmonary Adenocarcinoma Model for Human Lung Cancer

This study reports the findings from 9 sheep that received sensor implantations. Time taken from initial CT scans to the placement of a single sensor into an OPA tumour was 45 ± 5 min, with all implantations resulting in the successful delivery of sensors into tumours. Immediate post-implantation mild pneumothoraces occurred in 4 sheep, which was successfully managed in all cases. This is, to the best of our knowledge, the first description of the use of naturally-occurring OPA cases as a pre-clinical surgical model. Through the integration of techniques used in the treatment of human lung cancer patients, including ultrasound, general anaesthesia, CT and surgery into the OPA model, we have demonstrated its translational potential. Although our research was tailored specifically for the implantation of sensors into lung tumours, we believe the model could also be developed for other pre-clinical applications.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research