Role of CaMKII in Cardiac Arrhythmias

Protein phosphorylation is a central mechanism in vertebrates for the regulation of signaling. Relevant for the cardiovascular system, phosphorylation of myocyte targets is critical for regulation of excitation contraction coupling, metabolism, intracellular calcium regulation, mitochondrial activity, transcriptional regulation, and cytoskeletal dynamics. In fact, relevant for this review, pathways that tune protein kinase signaling have been a mainstay for cardiovascular therapies for the past sixty years.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research