Structural and Functional Brain Alterations in Post-traumatic Headache Attributed to Mild Traumatic Brain Injury: A Narrative Review

Conclusions: PTH attributed to mTBI is associated with abnormalities in brain structure and function that can be detected via research imaging. Additional studies are needed to determine the specificity of the findings for PTH, to differentiate findings attributed to PTH from those attributed to the underlying TBI and coexistent post-TBI symptoms, and to determine the accuracy of imaging findings for predicting the development of PPTH.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Discussion Basilar skulls fractures are relatively common occurring in 4-20% of all skull fractures. Motor vehicle accidents, significant falls from heights and blunt trauma are the most common causes of basilar skull fractures. Basilar skulls fractures are even less common in children than adults. Complications can include meningitis, cerebrospinal fluid (CSF) leaks, cranial nerve injuries or even potentially death. With more significant trauma to the head and body, it is not surprising that complications are more likely. Nasoethmoid facial fractures have similar common mechanisms of injury including motor vehicle accid...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSION: Future directions for behavioral management of headache triggers as a potential treatment for chronic post-traumatic headaches after mTBI are discussed. PMID: 31256091 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
Post-traumatic headache (PTH) is one of the most common, debilitating, and difficult symptoms to manage after a traumatic head injury. Although the mechanisms underlying PTH remain elusive, recent studies in rodent models suggest the potential involvement of calcitonin gene–related peptide (CGRP), a mediator of neurogenic inflammation, and the ensuing activation of meningeal mast cells (MCs), proalgesic resident immune cells that can lead to the activation of the headache pain pathway. Here, we investigated the relative contribution of MCs to the development of PTH-like pain behaviors in a model of mild closed-head i...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Conclusions: Pre-injury psychiatric and pre-injury headache/migraine symptoms are risk factors for worse functional and post-concussive outcomes at 3- and 6-months post-mTBI. mTBI patients presenting to acute care should be evaluated for psychiatric and headache/migraine history, with lower thresholds for providing TBI education/resources, surveillance, and follow-up/referrals. Clinical Trial Registration:, identifier NCT01565551. Introduction Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality worldwide. In 2013 ~2.8 million TBI cases were recorded annually i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Persistent post-traumatic headache (PTH) and chronic migraine (CM) often present with clinically overlapping features including prominent light sensitivity. Dynamic pupillometry is a promising new tool for evaluation of autonomically mediated responses to light in headache disorders, as they may differ between headache phenotypes. While our prior work has evaluated autonomic responses in chronic migraine and mild traumatic brain injury (aka concussion), differences in PTH and chronic migraine have not been explored.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Conditions:   Post-Traumatic Headache;   Concussion, Mild Interventions:   Drug: Calcitonin Gene-Related Peptide;   Drug: Placebo Sponsor:   Danish Headache Center Recruiting
Source: - Category: Research Source Type: clinical trials
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