What Is the Significance of Rete Testis Invasion by Malign Germ Cell Tumor and Does Hilum Predict Metastasis?

Conclusions: We concluded that there is a strong association between hilar soft tissue invasion and vascular invasion. Especially in NS germ cell tumors, hilar soft tissue involvement a risk factor for prognosis and to determine the need for additional treatment. According to our study, hilar soft tissue status should be reported on routine pathology report.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research

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CONCLUSIONS: - Most changes occurred in the germ cell tumor classification, including replacement of the terms intratubular germ cell neoplasia unclassified and carcinoma in situ by germ cell neoplasia in situ; subdivision of the tumors into 2 main categories, those derived from germ cell neoplasia in situ and those not derived from germ cell neoplasia in situ; distinction of germ cell neoplasia in situ from germ cells with delayed maturation and pre-germ cell neoplasia in situ; expansion of the trophoblastic tumor category to include epithelioid trophoblastic tumor and cystic trophoblastic tumor; and substitution of sperm...
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
Conclusions: This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864 Received: 25 July 2016 Revised: 16 December 2016 Accepted: 22 December 2016 Published: 30 June 2017 Address correspondence to J. Schüz, Section of Environment and Radiation, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France. Telephone: +33 (0)4 72 73 84 41. Email: Schuzj@iarc.fr Supplemental Material is available online (https://doi.org/10.1289/EHP864). The authors declare they have no actual or potential competing finan...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
AbstractTesticular germ cell tumors (GCTs) comprise 2% of all human male malignancies and are the most common solid tumors in men between ages 15 and 35 years. Risk of contralateral testicular GCT is between 1 and 5%. Partial orchidectomy (PO) was originally described in 1984 by Richie. The evolving indications include metachronous tumors and tumor in solitary testicles. Also, small non-palpable lesions detected only by ultrasonography (USG) in asymptomatic patients is another indication. Salvagability is only chosen for tumors less than 2 cm in size. The key feature of PO is an inguinal approach with early vascular contro...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Testicular germ cell tumor (TGCT) is the most common malignancy in young men in most western countries. The incidence is highest in Northern European populations, where the incidence rates have increased significantly over the past decades. Genetic predisposition and conditions during pregnancy play a central role in TGCT development, and the disease arises from primordial germ cells that develop into carcinoma in situ (CIS) lesions. These lesions may develop into cancer from puberty onwards. Like primordial germ cells, CIS cells retain a permissive chromatin structure, indicating the involvement of epigenetic components i...
Source: Cancer Prevention Research - Category: Cancer & Oncology Authors: Tags: Bioinformatics and ' Omics : Poster Presentations - Proffered Abstracts Source Type: research
Background: Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particular, a comprehensive analysis of microRNA (miRNA), PIWI-interacting RNAs (piRNAs), and tRNA-derived small RNAs in human testis and testicular germ cell tumor (TGCT) is lacking. Results: We performed small RNA sequencing on 22 human TGCT samples from 5 histological subtypes, 3 carcinoma in situ, and 12 normal testis samples. miRNA was the most common group among the sequences 18–24 nt in length an...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Source Type: research
Small non-coding RNAs play essential roles in tumorigenesis. However, their role in testicular germ cell tumor (TGCT), the most common malignancy in young males in most western countries, is largely unknown. In particular, a comprehensive analysis of the small RNA composition, including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), and tRNA-derived small RNAs and their interactions, are lacking. tRNA-derived small RNAs have been shown to bind to the piRNA-associated protein HIWI2, indicating crosstalk between small RNA pathways.We have employed small RNA sequencing on 22 human TGCT samples from 5 histological subtype...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
Background Screening programmes for contralateral carcinoma in situ (CIS) testis in patients with unilateral germ-cell cancer (GCC) have never been evaluated. We investigated the effect of screening for contralateral CIS in a large nation-wide, population-based study. Patients and methods A contralateral single-site biopsy was offered to 4130 patients in whom GCC had been diagnosed in 1984–2007 (screened cohort); 462 patients in whom GCC was diagnosed in 1984–1988 comprised the unscreened cohort. Cases with CIS were offered radiotherapy. Initially CIS-negative biopsies in patients with metachronous GCC were re...
Source: Annals of Oncology - Category: Cancer & Oncology Authors: Tags: urogenital tumors Source Type: research
Abstract Malignant testicular germ cell tumors (TGCT) are the most frequent cancers in Caucasian males (20-40 years) with an 70% increasing incidence the last 20 years, probably due to combined action of (epi)genetic and (micro)environmental factors. It is expected that TGCT have carcinoma in situ(CIS) as their common precursor, originating from an embryonic germ cell blocked in its maturation process. The overall cure rate of TGCT is more than 90%, however, men surviving TGCT can present long-term side effects of systemic cancer treatment. In contrast, men diagnosed and treated for CIS only continue to live witho...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
Conclusions: Our findings provide the first comparison of DBP effects on germ cell number, differentiation, and aggregation in human testis xenografts and in vivo in rats. We observed comparable effects on germ cells in both species, but the effects in the human were muted compared with those in the rat. Nevertheless, phthalate effects on germ cells have potential implications for the next generation, which merits further study. Our results indicate that the rat is a human-relevant model in which to explore the mechanisms for germ cell effects. Citation: van den Driesche S, McKinnell C, Calarrão A, Kennedy L, H...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article March 2015 Source Type: research
Between 2% and 5% of malignant germ-cell tumors in men arise at extragonadal sites. Of extragonadal germ cell tumors, testicular carcinoma in situ (CIS) are present in 31–42% of cases, and CIS are reported to ...
Source: BMC Urology - Category: Urology & Nephrology Authors: Source Type: research
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