Clathrin-mediated Endocytosis of Alpha-1 Antitrypsin is Essential for its Protective Function in Islet Cell Survival
Conclusion: Our results suggest that AAT is internalized by β cells through clathrin-mediated endocytosis that leads to the suppression of caspase 9 activation. This process is required for the protective function of AAT in islets when challenged with proinflammatory cytokines or after islet transplantation.
Source: Theranostics - Category: Molecular Biology Authors: Jingjing Wang, Wenyu Gou, Do-sung Kim, Charlie Strange, Hongjun Wang Tags: Research Paper Source Type: research
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