SpaceOAR Hydrogel Improves Neurovascular Bundle Dosimetry in MRI Guided HDR Brachytherapy

Radiation induced erectile dysfunction (RiED) remains a significant problem for patients undergoing radiation therapy (RT) for prostate cancer. SpaceOAR (Augmenix, Boston MA) hydrogel is placed in the rectoprostatic space to displace the prostate from the rectum and has demonstrated to reduce rectal toxicity. SpaceOAR hydrogel patients receiving EBRT were also more likely to preserve sexual function in a phase III trial. While the proposed mechanism of this improvement was via lower mean radiation doses to the penile bulb, both groups of patients received RT doses below the published dose-tolerances of this structure.

Source: Brachytherapy - April 30, 2019 Category: Cancer & Oncology Authors: Kunal Saigal, Deborah Schofield, Nina Nguyen, Ha Pham, Matthew Biagioli Source Type: research