Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesis

Sepsis-induced cardiomyopathy contributes to the high mortality of septic shock in critically ill patients. Since the underlying mechanisms are incompletely understood, we hypothesized that sepsis-induced impairment of sirtuin 3 (SIRT3) activity contributes to the development of septic cardiomyopathy.

Source: Journal of Molecular and Cellular Cardiology - June 11, 2019 Category: Cytology Authors: Christoph Koentges, Mar ía C. Cimolai, Katharina Pfeil, Dennis Wolf, Timoteo O. Marchini, Aleksandre Tarkhnishvili, Michael M. Hoffmann, Katja E. Odening, Philipp Diehl, Constantin von zur Mühlen, Silvia Alvarez, Christoph Bode, Andreas Zirlik, Heiko Bu Source Type: research