Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy.

Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy. Int J Hematol. 2019 Jun 10;: Authors: Yamazaki H, Ohta K, Iida H, Imada K, Obara N, Tokumine Y, Tomiyama Y, Usuki K, Imajo K, Miyamura K, Sasaki O, Fanghong Z, Hattori T, Tajima T, Matsuda A, Nakao S Abstract Eltrombopag, an oral thrombopoietin-receptor agonist, stimulates hematopoiesis in patients with acquired aplastic anemia (AA) and has higher exposure in patients of East Asian origin. We evaluated the pharmacokinetics, efficacy, and safety of eltrombopag in Japanese patients with AA refractory or intolerant to immunosuppressive therapy (IST). Twenty-one patients (15 with non-severe AA, six with severe AA) with platelet counts
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research

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Conclusion: The epidemiological picture of TB showed that males were predominant in our study however female were more affected in younger age group compared to male. More than 51% of the cases were in productive age group which affects the socioeconomic condition of family and society. More than 2/3 of patients were from lower socioeconomic group with low BMI. Therefore improving nutrition and immunity can play an important role. 2.3% of the cases were HIV reactive and were on ART. Co-morbidities like COPD and Diabetes were seen in our study which were statistically significant and had impact on the treatment outcome of r...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionsIt is difficult to clarify whether the cauda equina tumor is benign or malignant based only on Magnetic resonance imaging findings. Clinicians should consider the possibility of metastasis when planning the surgery for intradural cauda equina tumor extirpation.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
In today ’s Daily Brief: UN stands in solidarity with Japan; avoid panic over DR Congo Ebola emergency; ‘transformative shift’ needed towards family-friendly work policies; hottest June EVER; Venezuelan migrant dangers; stop targeting Afghanistan civilians call.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
Publication date: 1 November 2019Source: Carbohydrate Polymers, Volume 223Author(s): Beata Kaleta, Andrzej Górski, Radosław Zagożdżon, Marcin Cieślak, Julia Kaźmierczak-Barańska, Barbara Nawrot, Marzenna Klimaszewska, Eliza Malinowska, Sandra Górska, Jadwiga TurłoAbstractWe hypothesized that selenium(Se)-enriched polysaccharides would possess superior biological activity when compared to those non-enriched. To verify this hypothesis, we obtained by biotechnological methods a Se-enriched analog of Japanese anticancer drug lentinan and, as a reference, the non-Se-enriched fraction. We tested the effects ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
CONCLUSION: Dementia risk was higher for individuals with low trajectories for serum albumin and hemoglobin levels. This finding highlights the importance of interventions that improve nutritional status and control relevant diseases in middle-aged and older adults with low serum albumin and hemoglobin levels. PMID: 31315125 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
ConclusionsAge, anemia (lower Hb), and increased hematopoietic activity (higher RDW) are the predominant predictors of ADC and the visibility of red marrow on DWI. Fat-suppression methods and bone-marrow physiology in middle-aged females may have affected the measured correlations between ADC and PDFF inconsistent with previous studies.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndrome With Excess Blasts-2 Interventions:   Drug: Gilteritinib;   Drug: Midostaurin Sponsors:   Stichting Hemato-Oncologie voor Volwassenen Nederland;   Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG);   Astellas Pharma Global Development, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article is excerpted from Roberts &Kreuz’s book “Becoming Fluent: How Cognitive Science Can Help Adults Learn a Foreign Language.” This article originally appeared on MIT Press Reader. Read the original article here.  
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Aging syndication Source Type: news
Publication date: Available online 18 July 2019Source: The LancetAuthor(s): Bin Zhou, Goodarz Danaei, Gretchen A Stevens, Honor Bixby, Cristina Taddei, Rodrigo M Carrillo-Larco, Bethlehem Solomon, Leanne M Riley, Mariachiara Di Cesare, Maria Laura Caminia Iurilli, Andrea Rodriguez-Martinez, Aubrianna Zhu, Kaveh Hajifathalian, Antoinette Amuzu, José R Banegas, James E Bennett, Christine Cameron, Yumi Cho, Janine Clarke, Cora L CraigSummaryBackgroundAntihypertensive medicines are effective in reducing adverse cardiovascular events. Our aim was to compare hypertension awareness, treatment, and control, and how they hav...
Source: The Lancet - Category: General Medicine Source Type: research
Conclusion:These results demonstrate that romiplostim is quite effective and well-tolerated in adult patients with AA ineligible or refractory to IST.DisclosuresTomiyama: Sysmex Corporation: Consultancy; Kyowa Hakko Kirin Co., Ltd.: Honoraria; Chugai Pharmaceutical Co., Ltd.: Honoraria; Novartis Pharma Co., Ltd.: Honoraria, Membership on an entity's Board of Directors or advisory committees. Lee: Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria, Research Funding. Miyazaki: Kyowa Hakko Kirin Co., Ltd.: Honoraria, Research Funding; Novartis Pharma Co., Ltd.: Honoraria. Usuki: Novartis: Speakers Bureau; Ono Pharmaceutica...
Source: Blood - Category: Hematology Authors: Tags: 508. Bone Marrow Failure: Poster I Source Type: research
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