Flurbiprofen inhibits androgen productions in rat immature Leydig cells.

In conclusion, flurbiprofen directly inhibits HSD3B activity and the expression levels of Srd5a1 and Akr1c14 in rat Leydig cells, thus leading to the reduction of androgen secretion.
PMID: 31184881 [PubMed - as supplied by publisher]

Source: Cell Research - June 10, 2019 Category: Cytology Authors: Wang Y, Zheng W, Shan Y, Qiu L, Dong Y, Ni C, Li X, Huang T, Zhu Q, Lian Q, Ge RS Tags: Chem Res Toxicol Source Type: research