The Complexity of PRC2 Subcomplexes.

The Complexity of PRC2 Subcomplexes. Trends Cell Biol. 2019 Jun 06;: Authors: van Mierlo G, Veenstra GJC, Vermeulen M, Marks H Abstract Polycomb repressive complex 2 (PRC2) is a multisubunit protein complex essential for the development of multicellular organisms. Recruitment of PRC2 to target genes, followed by deposition and propagation of its catalytic product histone H3 lysine 27 trimethylation (H3K27me3), are key to the spatiotemporal control of developmental gene expression. Recent breakthrough studies have uncovered unexpected roles for substoichiometric PRC2 subunits in these processes. Here, we elaborate on how the facultative PRC2 subunits regulate catalytic activity, locus-specific PRC2 binding, and propagation of H3K27me3, and how this affects chromatin structure, gene expression, and cell fate. PMID: 31178244 [PubMed - as supplied by publisher]
Source: Trends in Cell Biology - Category: Cytology Authors: Tags: Trends Cell Biol Source Type: research