Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein [Neuroscience]

Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. FXS is caused by loss of expression of fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates translation of numerous mRNA targets, some of which are present at synapses. While protein synthesis deficits have...

Source: Proceedings of the National Academy of Sciences - June 10, 2019 Category: Science Authors: Ying Yang, Yang Geng, Dongyun Jiang, Lin Ning, Hyung Joon Kim, Noo Li Jeon, Anthony Lau, Lu Chen, Michael Z. Lin Tags: Biological Sciences Source Type: research