Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation [Immunology and Inflammation]
The cyclic GMP-AMP synthase (cGAS)–cGAMP–STING pathway plays a key role in innate immunity, with cGAS sensing both pathogenic and mislocalized DNA in the cytoplasm. Human cGAS (h-cGAS) constitutes an important drug target for control of antiinflammatory responses that can contribute to the onset of autoimmune diseases. Recent studies have established...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Wei Xie, Lodoe Lama, Carolina Adura, Daisuke Tomita, J. Fraser Glickman, Thomas Tuschl, Dinshaw J. Patel Tags: PNAS Plus Source Type: research
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