Four-year outcomes from a prospective phase II clinical trial of moderately hypofractionated proton therapy for localized prostate cancer
This study was performed to determine the clinical and patient-reported outcomes for patients with PC treated with HFPT.
First, and perhaps most importantly, Dinh et al are to be applauded for presenting their prospective series of men treated with proton therapy at the University of Washington and their carefully reported rectal toxicity outcomes in the context of dose-volume histogram analysis as well as differing rectal immobilization devices.1 These result s provide strong evidence suggesting that without the use of a rectal spacer, there is increased rectal toxicity with proton therapy compared with intensity modulated radiation therapy (IMRT).
CONCLUSION: The proposed mp-MRI-guided DIL boost using proton radiation therapy is feasible without violating OAR constraints and demonstrates a potential clinical benefit by improving DIL TCP. This retrospective study suggested the use of IMPT-based DIL SIB may represent a strategy to improve tumor control. ADVANCES IN KNOWLEDGE: This study investigated the planning of mp-MRI-guided DIL boost in prostate proton radiation therapy and estimated its clinical impact with respect to TCP and NTCP. PMID: 31904261 [PubMed - as supplied by publisher]
PMID: 31166085 [PubMed - as supplied by publisher]
Abstract The purpose of this study was the evaluation of the impact of a variable relative biological effectiveness (RBE) compared to a constant RBE value of 1.1 in proton therapy prostate trials due to uncertainties in α/β ratio. Twenty patients receiving passive scattered proton therapy (PSPT) and fifteen patients receiving intensity modulated proton therapy (IMPT) were compared to twenty patients treated with 7-field intensity modulated photon therapy (IMRT). For proton beam therapy (PBT), the RBE was estimated using two different RBE models. Tumor control probabilities (TCP) and n...
Authors: Podder TK, Fredman ET, Ellis RJ Abstract Major categories of radiotherapy (RT) for prostate cancer (CaP) treatment are: (1) external beam RT (EBRT), and (2) brachytherapy (BT). EBRT are performed using different techniques like three-dimensional conformal RT (3D-CRT), intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated proton therapy (IMPT), etc., using a variety of radiation delivery machines, such as a linear accelerator (Linac), Cyberknife robotic system, Gamma knife, Tomotherapy a...
(Northwestern Memorial HealthCare) Proton therapy treatment for prostate cancer is associated with higher survival rates and decreased risk of complications compared to intensity-modulated radiation therapy (IMRT) according to a new study by researchers at the Northwestern Medicine Chicago Proton Center.
Abstract Prostate cancer treatment with definitive radiation therapy (RT) has evolved dramatically in the past 2 decades. From the initial 2-dimensional planning using X-rays, advances in technology led to 3-dimensional conformal RT, which used computerized tomography-based planning. This has allowed delivery of higher doses of radiation to the prostate while reducing dose to the surrounding organs, resulting in improved cancer control. Today, intensity-modulated RT (IMRT) is considered standard, where radiation beams of different shapes and intensities can be delivered from a wide range of angles, thus further de...
For prostate cancer, radiation therapy options include external beam and brachytherapy.We compare the following radiation therapy modalities for prostate cancer using evidence grading: conventional fractionation, hypofractionation, stereotactic body radiation therapy, proton therapy, low dose rate brachytherapy, high dose rate brachytherapy, and brachytherapy boost.Outcomes and toxicity profiles of the modalities are juxtaposed.Contraindications of options are provided, based on current randomized trials.
Men with aggressive prostate cancer who are treated with radiation at a high-volume...Read more on AuntMinnie.comRelated Reading: Interrupted radiation therapy risks cancer recurrence ASTRO: Shorter RT works for low-risk prostate cancer Shortened RT for prostate cancer may not be better Prostate cancer rad therapy may cause other cancers Proton therapy succeeds in treating prostate cancer
Nature Reviews Urology 13, 181 (2016). doi:10.1038/nrurol.2016.50 Author: Peter Sidaway Patients with prostate cancer often receive treatment with external beam radiation therapy (EBRT); however, this approach can also expose non-malignant tissue to radiation, resulting in adverse events. Now, long-term data are available demonstrating that image-guided proton therapy, which delivers radiation in a more targeted manner,