Four-year outcomes from a prospective phase II clinical trial of moderately hypofractionated proton therapy for localized prostate cancer

This study was performed to determine the clinical and patient-reported outcomes for patients with PC treated with HFPT.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

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PMID: 31166085 [PubMed - as supplied by publisher]
Source: Journal of Applied Clinical Medical Physics - Category: Physics Authors: Tags: J Appl Clin Med Phys Source Type: research
Abstract The purpose of this study was the evaluation of the impact of a variable relative biological effectiveness (RBE) compared to a constant RBE value of 1.1 in proton therapy prostate trials due to uncertainties in α/β ratio.
 
 Twenty patients receiving passive scattered proton therapy (PSPT) and fifteen patients receiving intensity modulated proton therapy (IMPT) were compared to twenty patients treated with 7-field intensity modulated photon therapy (IMRT). For proton beam therapy (PBT), the RBE was estimated using two different RBE models. Tumor control probabilities (TCP) and n...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
Authors: Podder TK, Fredman ET, Ellis RJ Abstract Major categories of radiotherapy (RT) for prostate cancer (CaP) treatment are: (1) external beam RT (EBRT), and (2) brachytherapy (BT). EBRT are performed using different techniques like three-dimensional conformal RT (3D-CRT), intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated proton therapy (IMPT), etc., using a variety of radiation delivery machines, such as a linear accelerator (Linac), Cyberknife robotic system, Gamma knife, Tomotherapy a...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
(Northwestern Memorial HealthCare) Proton therapy treatment for prostate cancer is associated with higher survival rates and decreased risk of complications compared to intensity-modulated radiation therapy (IMRT) according to a new study by researchers at the Northwestern Medicine Chicago Proton Center.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Prostate cancer treatment with definitive radiation therapy (RT) has evolved dramatically in the past 2 decades. From the initial 2-dimensional planning using X-rays, advances in technology led to 3-dimensional conformal RT, which used computerized tomography-based planning. This has allowed delivery of higher doses of radiation to the prostate while reducing dose to the surrounding organs, resulting in improved cancer control. Today, intensity-modulated RT (IMRT) is considered standard, where radiation beams of different shapes and intensities can be delivered from a wide range of angles, thus further de...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
For prostate cancer, radiation therapy options include external beam and brachytherapy.We compare the following radiation therapy modalities for prostate cancer using evidence grading: conventional fractionation, hypofractionation, stereotactic body radiation therapy, proton therapy, low dose rate brachytherapy, high dose rate brachytherapy, and brachytherapy boost.Outcomes and toxicity profiles of the modalities are juxtaposed.Contraindications of options are provided, based on current randomized trials.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Source Type: research
Men with aggressive prostate cancer who are treated with radiation at a high-volume...Read more on AuntMinnie.comRelated Reading: Interrupted radiation therapy risks cancer recurrence ASTRO: Shorter RT works for low-risk prostate cancer Shortened RT for prostate cancer may not be better Prostate cancer rad therapy may cause other cancers Proton therapy succeeds in treating prostate cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Nature Reviews Urology 13, 181 (2016). doi:10.1038/nrurol.2016.50 Author: Peter Sidaway Patients with prostate cancer often receive treatment with external beam radiation therapy (EBRT); however, this approach can also expose non-malignant tissue to radiation, resulting in adverse events. Now, long-term data are available demonstrating that image-guided proton therapy, which delivers radiation in a more targeted manner,
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research
CONCLUSIONS: Three-dimensional conformal radiotherapy has long been the standard of care for percutaneous radiotherapy. The development of intensity-modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT) have increased the precision of treatment, thus, reducing side effects and allowing dose escalation. LDR (low dose rate) and HDR (high dose rate) brachytherapy alone or in combination are a treatment option in localized prostate cancer with a distinct side effect profile. The roles of proton therapy and stereotactic radiotherapy should be further investigated in prospective trials. PMID: 26895435...
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
To quantify and compare the impact of interfractional setup and anatomic variations on proton therapy (PT) and intensity modulated radiation therapy (IMRT) for prostate cancer.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research
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