Molecular and histological correlations in liver cancer

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular and histological level. High-throughput sequencing and gene expression profiling have identified distinct transcriptomic subclasses and numerous recurrent genetic alterations, and several HCC subtypes characterized by histological features have also been identified. HCC phenotype appears to be closely related to particular gene mutations, tumor subgroups and/or oncogenic pathways. Non-proliferative tumors display a well-differentiated phenotype, and among this molecular subgroup, CTNNB1 mutated HCC constitute a homogeneous subtype with cholestasis and microtrabecular and pseudoglandular architectural patterns.

Source: Journal of Hepatology - June 9, 2019 Category: Gastroenterology Authors: Julien Calderaro, Marianne Ziol, Val érie Paradis, Jessica Zucman-Rossi Tags: Review Source Type: research