Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin.

CONCLUSION: Our study suggested that Nek2B can bind to β-catenin and the co-expression correlated with TNBC patients poor prognosis. It appears that Nek2B and β-catenin might synergize to promote chemotherapy resistance.
PMID: 31174562 [PubMed - in process]

Source: Clinical Genitourinary Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Shen H, Yan W, Yuan J, Wang Z, Wang C Tags: J Exp Clin Cancer Res Source Type: research