Malaria smear positivity among Kenyan children peaks at intermediate temperatures as predicted by ecological models

Ambient temperature is an important determinant of malaria transmission and suitability, affecting the life-cycle of the Plasmodium parasite and Anopheles vector. Early models predicted a thermal malaria transmis...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

Related Links:

Blood smear microscopy remains the gold-standard method to diagnose and quantify malaria parasite density. In addition, parasite genotyping of select loci is the most utilized method for distinguishing recrude...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
ConclusionsMass azithromycin distributions were associated with a reduced prevalence of malaria parasitemia in this trial, suggesting one possible mechanism for the mortality benefit observed with this intervention. Trial registrationThe trial was registered on ClinicalTrials.gov (NCT02048007).
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ute;M Abstract Avian malaria is a widespread infection caused by parasites from the Order Haemosporida. Indeed, Neotropical swifts are interesting models for host-parasite coevolution studies due to their unique life history that may allow them to escape parasitism. Considering this, we evaluated haemosporidians from Neotropical swifts. We collected blood and prepared smears from 277 individuals from waterfalls in Brazil. Despite low parasitemia or absence of parasites detected by microscopy haemosporidian infection was detected in 44 swifts (15.8%) using a screening PCR that amplifies a 154-nucleotide segment of ...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
We reported a case of Plasmodium ovale infection in a young Indonesian Soldier following one year mefloquine prophylaxis 250 mg weekly. Typical fever and chills were experienced two weeks after returning from one year duty in Congo, West-Central Africa. The diagnosis of ovale malaria was made by peripheral blood smear, and 35/250 parasites in small microscopic view was found. Then, he recovered after dihydroartemisin and primaquine combination therapy. This was an unusual case of long-term prophylaxis failure since mefloquine has been recognized as the agent for malaria prevention, even multi-drug-resistance Plasmodium. Do...
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
This study including human samples was carried out in accordance with the recommendations of the ICH/GCP guidelines, Comité de Etica para Investigación con Humanos, Centro Internacional de Vacunas (CECIV, Cali, Colombia), and the protocol approved by the CECIV. All subjects gave written informed consent in accordance with the Declaration of Helsinki. All animal protocols that include experimental animal procedures using mice and NHP were carried out in accordance with the US Animal Welfare Act and approved by the Emory University's Institutional Animal Care and Use Committee and followed accordingly....
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study led to biomarker qualification through the U.S. Food and Drug Administration for use in CHMI studies at non-endemic sites, which will facilitate biomarker use for the qualified context of use in drug and vaccine trials. PMID: 31017084 [PubMed - as supplied by publisher]
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Tags: Am J Trop Med Hyg Source Type: research
This reporter line has been used to analyze liver infection in immune-deficient humanized mice engrafted with human liver tissue ((Sack et al., 2014; Flannery et al., 2018); (Foquet et al., 2018)). In multiple RMP transgenic lines the uis4 gene promoter has been used to drive expression of different transgenes in sporozoites and liver-stages, such as genes encoding mCherry, ovalbumin or human Plasmodium proteins (Combe et al., 2009; Panchal et al., 2012; Montagna et al., 2014; Hopp et al., 2015; Longley et al., 2015, 2017; Singer et al., 2015) The uis4 gene, a member of the small Plasmodium etramp gene family, is highly t...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions Nucleoside hydrolases are vital enzymes for the replication of Leishmania, conserved phylogenetic marker of the genus and strong-specific immunogens. We demonstrated that NH36 is an excellent target for chemotherapy of visceral leishmaniasis. Searching for the most immunogenic fraction of promastigotes of Leishmania we described the FML antigen of L. (L.) donovani, that has as its main component, the NH36 Nucleoside hydrolase. We developed second–generation vaccines with the FML and the NH36 native antigens, and with the NH36 recombinant protein. In addition, we obtained a third generation vaccine based ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Monti M Abstract A sailor for forty-two years, in military service on the Italian aircraft carrier, while on a mission in sub-Saharan Africa, came to a physician due to fatigue with a fever, flu-like illness and headache for 6 days. The temperature was 38.8°C, BP 80/145 mmHg and RR 30/min. The oxygen saturation was 88%, while the patient was breathing room air. Laboratory findings showed that WBC count and platelet counts were greatly reduced. Blood smears were positive for Plasmodium falciparum malaria with more than 10 parasites per field. It began immediately antimalarial treatment. After 24 hours t...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
This study aimed to determine the prevalence, to describe the clinical presentation, and to examine factors associated with congenital malaria in newborns aged up to 7 days attending Tororo General Hospital in Uganda. A total of 261 mother/baby pairs were recruited in this cross-sectional study. Giemsa-stained thick blood smears for malaria parasites and rapid malaria diagnostic tests were performed on capillary blood samples from all newborns and mothers, as well as on placental and cord samples from newborns delivered in the hospital. The prevalence of congenital malaria in the newborns was 16/261 (6.1%). No single clini...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Tags: Am J Trop Med Hyg Source Type: research
More News: Children | Kenya Health | Malaria | Microbiology | Papanicolaou (Pap) Smear | Parasitic Diseases | Parasitology