FDG PET/MRI Findings Pointing Toward a Gayet-Wernicke Encephalopathy

This report highlights ability of hybrid PET/MRI to investigate small neuronal structures, such as the MBs involved in Gayet-Wernicke disease.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Related Links:

This is an MRI image obtain in alcoholic beggar presented with ataxia, ophthalmoplegia and acute confusional state. Red arrow shows hyperintense signal around mamillary bodies and yellow arrow around periaqueductal area.Important Point :MRI  in wernicke's encephalopathy shows hyperintense T2/FLAIR signal involving the mamillary bodies, dorsomedial thalami, tectal plate, periaqueductal area, and around 3rd ventricle.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs
CONCLUSIONS: The development of a full triad and additional symptomatology suggests a late recognition of signs and symptoms of WE in schizophrenia. Prophylactic thiamine checks and treatment in patients with schizophrenia are relevant, and if WE is suspected adequate parenteral thiamine supplementation is necessary. Key points Only few cases of schizophrenia-related WE have been published in the literature, though challenges in diagnosing and recognising WE suggest that the vast majority of cases go undetected. Acute thiamine deficiency leads to Wernicke's Encephalopathy. Patients diagnosed with schizophrenia are at risk ...
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
In Reply We thank Sechi and Sechi for their interest in our recent article describing challenges in the diagnosis and management of alcohol withdrawal in medically ill hospitalized patients. We certainly agree that Wernicke encephalopathy (WE) should always be included in the differential diagnosis for delirium in patients with a history of heavy alcohol use, and parenteral thiamine should be provided empirically without delay. Urgent treatment with parenteral thiamine can reverse WE, whereas untreated patients may progress to permanent cognitive impairment and Korsakoff syndrome, coma, or death.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
To the Editor Alcohol withdrawal syndrome (AWS) and Wernicke encephalopathy (WE) are medical emergencies associated with considerable morbidity and mortality, and are still greatly underdiagnosed and misdiagnosed in clinical practice, either in primary or in secondary care. The best aid for diagnosis in both diseases, particularly in individuals with chronic alcohol misuse, is a detailed medical history. In particular, an accurate understanding of the natural history of alcohol withdrawal, including the temporal progression of neurological signs, is essential for a diagnosis of AWS, while an intelligent search for any fact...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Authors: Miyanaga R, Hisahara S, Ohhashi I, Yamamoto D, Matsumura A, Suzuki S, Tanimoto K, Hirakawa M, Kawamata J, Kato J, Shimohama S Abstract We herein report a patient with Wernicke-Korsakoff syndrome (WKS) who had neither a history of alcoholism or of history of gastric surgery. A 56-year-old female was transferred to our hospital because of the loss of consciousness and she was diagnosed to have Wernicke encephalopathy. She showed proton pump inhibitor-induced refractory hypergastrinemia with the subsequent development of hyperemesis and a vitamin B1 deficiency. PMID: 32669503 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Gayet-Wernicke encephalopathy (WE) is an acute neurological disorder resulting from deficiency of thiamine, commonly related to chronic abuse of alcohol, but frequently missed or overlooked as a diagnosis when a nonalcoholic patient presents with atypical signs and symptoms of the disease. The diagnosis of the disease is clinical, and confirmation is done by magnetic resonance imaging. We aim to highlight a case of WE in a nonalcoholic postoperative surgical patient receiving total parental nutrition where high-dose intravenous administration of thiamine in time mitigated the symptoms of disease and prevented permanent neu...
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Report Source Type: research
CONCLUSION: Although WE is rare in children it can be prevented by early diagnosis and treatment and oculomotor findings such as diplopia can be a warning sign. PMID: 32419425 [PubMed - in process]
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
This report describes a series of cases of WKS that were clinically evaluated by liaison psychiatrists on a nonpsychiatric inpatient unit. The cases illustrate a deficit in the recognition and adequate treatment of WKS, demonstrating its clinical complexity and the need to improve physicians' knowledge. PMID: 32391987 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
AbstractWernicke ’s encephalopathy (WE) is a severe and life-threatening illness resulting from vitamin B1 (thiamine) deficiency. The prevalence of WE has been estimated from 0.4 to 2.8%. If not treated properly, severe neurologic disorders such as Korsakoff psychosis and even death may occur. The classical triad of clinical symptoms (abnormal mental state, ataxia, and ophthalmoplegia) is found in only 16–33% of patients on initial examination. The originally described underlying condition of WE is alcoholism, but it accounts for about 50% of causes of WE. Nonalcoholic patients are also affected by WE and likel...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
More News: Alcoholism | Brain | Neurology | Nuclear Medicine | PET Scan | Vitamin B1 | Vitamins | Wernicke's Encephalopathy