The impact of left ventricle ejection fraction on heart failure patients with pulmonary hypertension

The most common cause of pulmonary hypertension (PH) in developed countries is left heart disease (LHD, group 2 PH). The development of PH in heart failure (HF) patients is indicative of worse outcomes.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research

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Pulmonary hypertension (PH) in the setting of left heart disease (PH-LHD) is the most common cause of PH in the general population, with a prevalence of up to 80% and is associated with high morbidity and mortality. We have previously demonstrated the utility of right ventricular outflow tract (RVOT) Doppler notching as a composite marker of pulmonary vascular disease (PVD) in patients with PH-associated with heart failure with preserved ejection fraction (HFpEF). Our study examines the ability of RVOT Doppler notching to predict survival in patients with PH-HFpEF.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 171 Source Type: research
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Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Review of Therapeutics Source Type: research
This article reviews the clinical application of stress echocardiography, including dobutamine, semisupine bicycle, treadmill, and leg-positive pressure for VHD patient management, and focuses on the current consensus regarding the use of stress echocardiography in VHD. Stress echocardiography is safe and should be encouraged, especially in heart valve clinics, to understand the complex mechanism in asymptomatic patients.
Source: Journal of Medical Ultrasonics - Category: Radiology Source Type: research
Publication date: Available online 5 June 2019Source: Heart &LungAuthor(s): Barak Zafrir, Shemy Carasso, Sorel Goland, Liaz Zilberman, Robert Klempfner, Nir Shlomo, Evgeny Radzishevsky, Tal Hasin, Avraham Shotan, Alicia Vazan, Jean Marc Weinstein, Wadi Kinany, Robert Dragu, Elad Maor, Liza Grosman-Rimon, Offer AmirAbstractBackgroundThe most common cause of pulmonary hypertension (PH) in developed countries is left heart disease (LHD, group 2 PH). The development of PH in heart failure (HF) patients is indicative of worse outcomes.ObjectiveThe aim of this study was to evaluate the long term outcomes of HF patients with ...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
AbstractPurpose of ReviewPulmonary hypertension (PH) frequently complicates heart failure and portends a worse prognosis. This review will summarize and discuss recent updates in the classification and management of patients with PH due to left heart disease.Recent FindingsCareful hemodynamic assessment is critical to the classification of patients with PH and heart failure. Two hemodynamic subgroups of PH in heart failure patients have been described: isolated post-capillary pulmonary hypertension and combined post- and precapillary pulmonary hypertension. The cornerstone in management of PH due to left heart disease is t...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Authors: Zolty R Abstract INTRODUCTION: Pulmonary hypertension (PH) secondary to left-sided heart disease (Group 2 PH) is a frequent complication of heart failure (HF) and is a heterogeneous phenotypic disorder that worsens exercise capacity, increases risk for hospitalization and survival independent of left ventricular ejection fraction (LVEF) or stage of HF. Areas covered: In this review, an update of the current knowledge and some potential challenges about the pathophysiology and treatments of group 2 PH in patients with HF of either preserved or reduced ejection fraction are provided. Also, this review discus...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
Pulmonary hypertension (PH) is a life-threatening condition and generally confers a poor prognosis. Among the various etiologies, left heart disease is the most common cause of the development of PH.1 The presence of PH in heart failure (HF) is associated with more severe symptom and worse exercise tolerance.2 PH also has negative impact on the clinical outcome both in HF with preserved ejection fraction (HFpEF)3 and reduced ejection fraction (HFrEF).4 Since the definite diagnosis of PH, defined as mean pulmonary artery pressure (mPAP) more than 25 mmHg, requires right heart catheterization, non-invasive methods such as tr...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
reiber J Abstract Pulmonary hypertension is a chronic, incurable disease with poor prognosis. The therapeutic aim is a stabilization of patients showing signs of right heart failure as well as disease progression. A pulmonary hypertension is diagnosed in patients displaying a mean pulmonary arterial pressure of> 25 mmHg in resting state. Invasively measured hemodynamics evaluated by right heart catheterization (mean pulmonary arterial pressure [mPAP], pulmonary arterial wedge pressure [PAWP], diastolic pressure gradient [DPG] and pulmonary vascular resistance [PVR]) allows to differentiate between...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - Category: Intensive Care Authors: Tags: Anasthesiol Intensivmed Notfallmed Schmerzther Source Type: research
This study aims to assess the usefulness of strain ‐encoded magnetic resonance (SENC) for the quantification of myocardial deformation (‘strain’) in healthy volunteers and for the diagnostic workup of patients with different cardiovascular pathologies. SENC was initially described in the year 2001. Since then, the SENC sequence has undergone s everal technical developments, aiming at the detection of strain during single‐heartbeat acquisitions (fast‐SENC). Experimental and clinical studies that used SENC and fast‐SENC or compared SENC with conventional cine or tagged magnetic resonance in phantoms, anim...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Review Source Type: research
The incidence of congenital heart disease (CHD) is about 4 to 10 per 1000 live births. While severe forms of CHD are usually diagnosed in infancy or childhood, milder and more survivable CHD may first manifest in the adult or may be discovered incidentally on imaging studies performed for other reasons. It is important to identify CHD in adults to implement appropriate treatment and prevent complications such as progression of pulmonary hypertension and development of heart failure. The goals of this article are to illustrate the appearance on computed tomography of various forms of uncorrected CHD in adults and describe t...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Web Exclusive Content-Pictorial Essay Source Type: research
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