The Efficacy and Underlying Mechanism of Phosphodiesterase- 5 inhibitors in Preventing Cognitive Impairment and Alzheimer Pathology: A Systematic Review of Animal Studies.

CONCLUSIONS: Cognitive decline in preclinical AD finds tauopathy has a more impact than Aβ-42. This systematic review showed that PDE-5 inhibitors might help prevent cognitive impairment in AD, and while its mechanism of action is non-related to Aβ-42, it might include decrease p-Tau, increase CREB and BDNF or suppressing apoptosis and inflammation. However, the efficacy of PDE-5 inhibitors in preventing cognitive impairment remains unclear due to various limitations, such as the small number of included studies, the high risk of bias, the lack of an integrated study design, and low reporting quality. PMID: 31163203 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31163203?dopt=Abstract

Source: Behavioural Brain Research - May 31, 2019 Category: Neurology Authors: Bakly WE, Wagdy O, Sobhy A, Abo Elenain O, Riad MS, El Sayed M, Tarkhan S, Yassen M, Mahmoud A, Bassiony M, Nabil N Tags: Behav Brain Res Source Type: research