Melatonin attenuates white matter damage after focal brain ischemia in rats by regulating the TLR4/NF- κB pathway.

CONCLUSIONS: In summary, melatonin could promote the proliferation of endogenous OPCs and suppress the expression of IL-1β protein via inhibiting TLR4/NF-κB signaling, thus alleviate the white matter damage in focal cerebral ischemic rats.
PMID: 31158461 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - May 30, 2019 Category: Neurology Authors: Zhao Y, Wang H, Chen W, Chen L, Liu D, Wang X, Wang X Tags: Brain Res Bull Source Type: research