Genotype distribution of Panton-Valentine leukocidin (PVL) positive Staphylococcus aureus strains isolated from wound related infections: A three year multi-center study in Tehran, Iran.

Genotype distribution of Panton-Valentine leukocidin (PVL) positive Staphylococcus aureus strains isolated from wound related infections: A three year multi-center study in Tehran, Iran. Jpn J Infect Dis. 2019 May 31;: Authors: Goudarzi M, Fazeli M, Pouriran R, Eslami G Abstract The spread of PVL-carrying S. aureus strains in patients with wound infections in both the community and hospitals are increasing in some areas of Iran. In the present study, we determined the molecular characteristics and distribution of PVL-producing S. aureus strains isolated in wound infections. Genes encoding resistance, toxin, and staphylococcal enterotoxins were analyzed by polymerase chain reaction assays. Genotyping was performed by using multi-locus sequence typing. Aminoglycoside resistance genes including ant (4΄)-Ia gene (57.4%) and aac (6΄)-Ie/aph (2˝) (45.7%) were the most prevalent genes in isolates. Staphylococcal enterotoxin type A, as the most frequent type, was present in 20.2% of isolates. Strains belonged to seven clonal complexes. The most frequent clonal complex was CC30 (ST30) (29.8%); followed by CC22 (ST22) (21.3%), CC8 (ST8 and ST931) (17%), CC88 (ST88) (10.6%), CC59 (ST59 and ST338) (8.5%), CC1 (ST772 and ST1) (7.5%), and CC15 (ST15) (5.3%). Our findings indicated an increasing trend of CC30, carrying a wide range of resistance and toxin genes that could be a dilemma for treating the patients with wound infections indeed. Furth...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research