18F-FDG PET/CT imaging in differential diagnosis of exudative pleural effusions
1332Objectives: To investigate the value of 18F-FDG PET/CT imaging in differentiating malignant from benign exudative pleural effusions. Methods: 224 patients with CT scan and pleural effusion puncture examination evidence of moderate or massive exudative pleural effusions entered the study to evaluate the accuracy of 18F-FDG PET/CT in differential diagnosis between malignant and benign exudative pleural effusions. Image analysis of PET/CT was performed both with visual interpretation and using a quantitative method on coronal, sagittal and axial reconstructions. The results of PET/CT imaging were compared to cyto- or histological data and at least one year follow-up results if diagnose as benign. Results: Ninety-three patients with exudative pleural effusion were confirmed as benign according to cyto- or histological data and at least one-year follow-up results. 114 patients with pleural effusion were caused by metastasis, and primary tumor was found in 99 patients using PET/CT. 12 patients were caused by mesothelioma and 5 patients wer caused by hematological cancer. There is significant difference of the pleural FDG activity grades between the benign and malignant pleural effusion (P
ConclusionPET/CT-guided molecular biopsy using Ga-68 labelled radiotracers is feasible and can be performed safely and accurately with a high-diagnostic yield. It is helpful in accurately staging the disease when tracer-avid isolated distant lesion evident on imaging and highly practical in patients with previous inconclusive sampling.
ConclusionsMRI may offer more superior diagnostic performance than CT for detecting T3-4 disease and EMVI, thereby supporting its alternative application to CT in local staging of colon cancer.
tro V Abstract Immunotherapy has been showed as a promisor treatment, in special for hematological diseases. Chimeric antigen receptor T cells (CARs) which are showing satisfactory results in early-phase cancer clinical trials can be highlighted. However, preclinical models are critical steps prior to clinical trial. In this way, a well-established preclinical model is an important key in order to confirm the proof of principle. For this purpose, in this chapter will be pointed the methods to generate tumor cells expressing firefly Luciferase. In turn, these modified cells will be used to create a subcutaneous and...
Abstract Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of activation and transduction, and culture supplementation. PMID: 31707678 [PubMed - in process]
Morphological appearance of Pleural nodules during thoracoscopy are not 100% diagnostic of Malignancy or TB. An early definite etiological diagnosis will help to decide the further treatment plan.Methods: During Medical thoracoscopy, Pulmonologist prepared Cytology smears slides directly from parietal pleura nodule biopsy tissue. Cytologist provided the smear cytology results in one day. Data were retrospectively reviewed, and Cytology results were compared with final pleural biopsy histopathology report.Results: 40 patients underwent Medical thoracoscopy for undiagnosed pleural effusion at a tertiary care hospital in Sout...
Conclusions: The overlap of pleural VEGF levels between the groups may limit the value of VEGF in discriminating between malignant versus benign and exudative versus transudative effusions; however, it may be a useful adjunct to various methods. The VEGF levels in pleural fluid seem to be related to the degree of inflammation and pleural invasion.
Publication date: Available online 17 June 2017 Source:Revista Clínica Española (English Edition) Author(s): F. Rodriguez-Panadero Pleural biopsies are especially indicated in the following circumstances: (a) inconclusive pleural fluid analysis and negative sputum study, if adenosine deaminase (ADA) levels are unavailable; (b) suspected multi-resistant tuberculosis; (c) a need for differentiating tuberculous pleurisy (if it progresses with neutrophilia) and complicated parapneumonic effusion; (d) malignant pleural effusion coexisting with very high ADA levels; (e) effusion coexisting with lung cancer and neg...
In conclusion, unilateral paraneoplastic pleural effusion in a nonsmoker male with occupational exposure to asbestosis fibers was suggestive for adenocarcinoma related asbestosis of the lung. Lung cancer and malignant pleural exudate developed after a long latency cumulative retention time of asbestos fibers. PMID: 28002541 [PubMed - in process]
Conclusion: MT has a great diagnostic yield that can be improved by practice, permitting to achieve a specific histological diagnosis in about 80% of patients. Our experience demonstrates that the accurate selection of the patients undergoing to MT is very important to reach these results.
Conclusions Advanced stages at presentation reflect the palliative pattern of treatment. Hypo-fractionated radiotherapy for lung and pleura malignancies as a palliative measure is the current practice. Implementation of early palliative care should be considered for metastatic patients.