Presentation and survival of multiple myeloma patients in Ghana: a review of 169 cases.

This report describes the clinic-pathological features of MM patients in Ghana at diagnosis, and the factors affecting their survival. Methods: A retrospective review of 169 MM cases diagnosed in a Ghanaian tertiary hospital from 2002-2016. Results: Median age was 58 years, with 29% ≤50 years. One-third presented>12 months after onset of symptoms, which included bone pain (96%), anaemia (67%), weight loss (55%) and fractures (44%). Myeloma-related tissue impairment included hypercalcaemia (36%), renal impairment (33%), severe anaemia (52%) and osteolytic lesions (76%); 51.3% of patients were diagnosed in ISS Stage III. Median survival was 33 months; 1-year and 5-year overall survival were 51.6% and 15.5%, respectively. Neither the age at diagnosis nor the duration of symptoms prior to diagnosis correlated with prognosis. Median survival improved with early ISS stage, haemoglobin>8g/dL, plasmacytosis
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research

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ConclusionActual body weight and bone marrow involvement may be utilized as potential predictive indicators of R-IRRs. Further study is needed to validate these indicators and determine appropriate utilization in practice.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conclusions: Women with deep invasive endometriosis who underwent IVF do not seem to be exposed to a substantially increased risk of recurrence/disease progression. Larger evidence from independent groups is however required for a definitive conclusion. PMID: 31517304 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Conclusions: A wide variety of analgesia protocols are used. The three most frequently used are i.v. administered opioids, i.m. administered opioids, and non-sedative oral analgesics. The variety of analgesia protocols is not desirable in the context of good clinical practice, and considering the risks of combining opioids and benzodiazepines. Monitoring of vital functions was only performed after administration of i.v. medication. A comparison of the pain scores could be a first step in finding the optimal method of analgesia, thereby forming the basis of guidelines for analgesia during oocyte retrieval. PMID: 31517299 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Publication date: Available online 15 September 2019Source: Journal of Materials Research and TechnologyAuthor(s): Withaya Panpa, Supatra Jinawath, Dujreutai Pongkao KashimaAbstractA visible light-active composite, Ag2O-Ag/CAC/SiO2, was produced by loading an aqueous silver salt solution onto the layer of hydrated calcium aluminate cement coating on porous SiO2 sphere. The mild cement hydration condition induced the formation of in situ Ag2O precipitates on the cement surface which were partially decomposed to metallic Ag after drying and appropriate heat treatment at 200 °C to enhance both decomposition and cryst...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR.
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Publication date: Available online 14 September 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Paul McCusker, John D. ChanAbstractSubversion of parasite neuromuscular function is a key strategy for anthelmintic drug development. Schistosome Ca2+ signaling has been an area of particular interest for decades, with a specific focus on L-type voltage-gated Ca2+ channels (Cavs). However, the study of these channels has been technically challenging. One barrier is the lack of pharmacological probes that are active on flatworms, since the dihydropyridine (DHP) based ligands typically used ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES. Trans Am Clin Climatol Assoc. 2019;130:88-99 Authors: Tsokos GC, Tsokos MG Abstract We have found that calcium calmodulin kinase IV is increased in T cells, podocytes, and mesangial cells from patients with systemic lupus erythematosus, as well as in lupus-prone mice, podocytes of patients with focal segmental glomerulosclerosis, and in mice injected with doxorubicin. We showed that this accounts for aberrant T cell function and glomerular damage. Using nanoparticles (nlg) loaded with a small drug inhibitor of calcium calmodulin ki...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
In this study, a new compound bearing the hexahydroquinoline ring analogous to 1,4-dihydropyridine structure was synthesized and its structure proved by instrumental techniques such as mass spectroscopy, 1H NMR, 13C NMR, IR and elemental analysis. In addition to the spectral methods used, X-ray study has been carried out to realize advanced studies on the structure of the mentioned compound. The analyses of single crystal X-ray diffraction show that the title compouns crystallized in the monoclinic system with space group P 21/n. Lattice constants are a = 7.1231(3) Å, b = 30.0033(19) Å, c = 11.8361(...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Multiple myeloma is a haematological disease in which clonal expansion of neoplastic plasma cells in the bone marrow causes production of monoclonal immunoglobulin [1,2]. The neoplastic plasma cells interact with the bone and bone marrow microenvironment commonly resulting in both local and generalised bone resorption leading to osteopenia and the formation of osteolytic ( ‘lytic’) lesions, visible under radiological and nuclear medicine examination as focal regions of low bone density. The presence of myeloma related bone disease is the most frequent cause of the debilitating symptoms, pain and pathological fr...
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research
A 50-year-old man was transferred to our hospital with a 3-week history of back pain and a mass on his skull that had been growing slowly for the past 7 months. The mass was smooth, firm, and non-tender. Despite his long hair, it gave him the appearance of having a high domed forehead. Examination was otherwise unremarkable. Laboratory investigations showed renal impairment, hypercalcaemia, anaemia, and immunoparesis. Lambda light chains were detected in the urine and the serum. Magnetic resonance scans of the brain (figure) and spine (appendix) showed soft tissue lesions over the skull and thoracic spine.
Source: LANCET - Category: General Medicine Authors: Tags: Clinical Picture Source Type: research
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