Obsessive-Compulsive Disorder and Growth Factors: A Comparative Review.

Obsessive-Compulsive Disorder and Growth Factors: A Comparative Review. Behav Brain Res. 2019 May 25;:111967 Authors: Savaheli S, Ahmadiani A Abstract The goal of this article is to clarify the role of various growth factors in the establishment and progression of obsessive-compulsive disorder (OCD). OCD is a chronic mental disorder with recurrent intrusive thoughts and/or repetitive compulsive behaviors that increase during stressful periods. Growth and neurotrophic factors may be contributing factors in the pathophysiology of OCD. Many of them are synthesized and released within the central nervous system and act as trophic agents in neurons; some of them are involved in brain growth, development, neurogenesis, myelination and plasticity, while others take part in the protection of the nervous system following brain injuries. This paper attempts to identify all articles investigating the relationship between OCD and neurotrophic and growth factors, in both animal and human studies, with a focus on adult brain studies. Based on the PubMed and Scopus and Science Direct search tools, the available articles and studies are reviewed. Out of 230 records in total, the ones related to our review topic were taken into account to further understand the pathophysiological mechanism(s) of OCD, providing methods to improve its symptoms via the modification of neurotrophins and growth factor imbalances. PMID: 31136772 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Abstract Over the last two decades, deep brain stimulation (DBS) has gained popularity as a treatment of severe and medically refractory obsessive-compulsive disorder (OCD), often using brain targets informed by historical lesional neurosurgical procedures. Paradoxically, the use of DBS in OCD has led some multidisciplinary teams to revisit the use of lesional procedures, especially anterior capsulotomy (AC), although significant aversion still exists toward the use of lesional neurosurgery for psychiatric disorders. This paper aims to review all literature on the use of AC for OCD to examine its effectiveness and...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Are you always in control and always perfectly put together? Are you professionally successful, a great friend, and always showing a happy face to the world?  But what about on the inside? Is there something in the background or in the past that you don’t talk about?  Do you feel disconnected, like no one knows the “real” you? Deep down do you just know something is wrong? Well, you might have “perfectly hidden depression.” Today Gabe speaks with Dr. Margaret Rutherford who has done extensive work on the relationship between perfectionism and depression.  Dr. Rutherford tells u...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Depression General Happiness Interview LifeHelper Mental Health and Wellness Perfectionism Personality Podcast Psychiatry Psychology Research Self-Esteem Self-Help The Psych Central Show Trauma Source Type: blogs
This cross-sectional study assesses whether deficits in goal-directed planning are better identified by self-reported compulsivity or a diagnosis of obsessive-compulsive disorder.
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
Exposure and ritual prevention (EX/RP) is an effective first-line treatment for obsessive-compulsive disorder (OCD), but only some patients achieve minimal symptoms following EX/RP. Herein, we investigate whether task-based neural activity can predict who responds best to EX/RP. Unmedicated adult patients with OCD (n = 36) and healthy participants (n =...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
This article describes findings about these cells made by others and myself that led us all from ignorance, via complete confusion, to our current state of knowledge. I believe I was fortunate to practice science in very supportive institutions and with very collaborative colleagues in two countries that both encourage independent research by independent scientists, while simultaneously ignoring or somehow being able to avoid some of the difficulties of being a woman in what was, at the time, a male-dominated profession. Expected final online publication date for the Annual Review of Immunology, Volume 38 is April 26, 2020...
Source: Annual Review of Immunology - Category: Allergy & Immunology Authors: Tags: Annu Rev Immunol Source Type: research
You're reading How to Prevent Your Anxiety from Rubbing Off On Your Child, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Sometimes, it seems like our kids aren’t learning anything from us—but that’s simply not the case. Kids absorb all the information around them and learn by example. While that can be a good thing, it can also be a problem if you don’t want to pass on certain behaviors you’re modeling for them, like anxiety. If you’re struggling with anxiety, first remember that...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression family featured psychology self improvement Source Type: blogs
CONCLUSIONS: Although drawing causal conclusions from the current research is impossible, the findings suggest that maladaptive CERSs may be a possible mechanism relating CM to alcohol craving and dependence in treatment-seeking alcohol-dependent individuals, while adaptive CERSs may be less important regarding this relation. However, the findings of the current study need longitudinal research. PMID: 31600610 [PubMed - as supplied by publisher]
Source: Child Abuse and Neglect - Category: Child Development Authors: Tags: Child Abuse Negl Source Type: research
The prevalence of obsessive-compulsive disorder (OCD) and obsessive and compulsive symptoms (OCS) is unclear both in the elderly and in people with Parkinson's disease (PD). Although the typical age of onset for OCD is around age 20 there is evidence for a second peak later in life at ages 65+.1 In PD, a disease of aging, studies have produced mixed results regarding an association with OCD and OCS.2 In this issue, Monaco et al.3 found additional evidence for this second peak in that elderly whether healthy or suffering from Parkinson's disease had an unexpectedly high percentage of OCS.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research
Authors: Gupta A, Khanna S, Jain R Abstract The main objective of this study is to assess the effectiveness of deep brain stimulation (DBS) of the ventral striatum (VS) of the anterior limb of internal capsule for patients suffering from refractory obsessive-compulsive disorder (OCD) and to compare its result with traditional anterior capsulotomy. The present study consisted of two patients subjected to stimulation of ventral capsule (VC)/VS region of internal capsule for refractory OCD. Leads were implanted on both sides stereotactically using fused images of magnetic resonance imaging and computed tomography scan...
Source: Indian Journal of Psychiatry - Category: Psychiatry Tags: Indian J Psychiatry Source Type: research
In this study we assessed the predictive power of quantitative EEG (qEEG) for the treatment response to right frontal transcranial magnetic stimulation (TMS) in obsessive compulsive disorder (OCD) using a machine learning approach. Method. The study included 50 OCD patients (35 responsive to TMS, 15 nonresponsive) who were treated with right frontal low frequency stimulation and identified retrospectively from Uskudar Unversity, NPIstanbul Brain Hospital outpatient clinic. All patients were diagnosed with OCD according to the DSM-IV-TR and DSM-5 criteria. We first extracted pretreatment band powers for patients. To explore...
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Tags: Clin EEG Neurosci Source Type: research
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